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GJB2 Produits

(Gap Junction Protein, beta 2, 26kDa (GJB2))
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008].

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Catégories GJB2 en vedette

GJB2 Anticorps

High quality antibodies with extensive validation data.

GJB2 Kits ELISA

Reliable ELISA kits for a wide range of species.

GJB2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

GJB2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7153609
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (4)
  • (2)
N° du produit ABIN544540
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, FACS
Validations
  • (3)
N° du produit ABIN190896
Quantité 100 μg
Fiche technique Fiche technique

GJB2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6966962
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6966961
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6956053
Quantité 96 tests
Fiche technique Fiche technique

GJB2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355142
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3097181
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3121332
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits GJB2

Moscato, Cabiati, Bianchi, Vaglini, Morales, Burchielli, Botta, Sabbatini, Falleni, Del Ry, Mattii: "Connexin 26 Expression in Mammalian Cardiomyocytes." dans: Scientific reports, Vol. 8, Issue 1, pp. 13975, (2018) (PubMed).

Tong, Lopez, Ramachandran, Ayad, Liu, Lopez-Rodriguez, Harris, Contreras: "Glutathione release through connexin hemichannels: Implications for chemical modification of pores permeable to large molecules." dans: The Journal of general physiology, Vol. 146, Issue 3, pp. 245-54, (2015) (PubMed).

Lopez, Gonzalez, Liu, Harris, Contreras: "Insights on the mechanisms of Ca(2+) regulation of connexin26 hemichannels revealed by human pathogenic mutations (D50N/Y)." dans: The Journal of general physiology, Vol. 142, Issue 1, pp. 23-35, (2013) (PubMed).

Alesutan, Sopjani, Munoz, Fraser, Kemp, Föller, Lang: "Inhibition of connexin 26 by the AMP-activated protein kinase." dans: The Journal of membrane biology, Vol. 240, Issue 3, pp. 151-8, (2011) (PubMed).

Djalilian, McGaughey, Patel, Seo, Yang, Cheng, Tomic, Sinha, Ishida-Yamamoto, Segre: "Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response." dans: The Journal of clinical investigation, Vol. 116, Issue 5, pp. 1243-53, (2006) (PubMed).

Ohtsuka, Yuge, Kimura, Namba, Abe, Van Laer, Van Camp, Usami: "GJB2 deafness gene shows a specific spectrum of mutations in Japan, including a frequent founder mutation." dans: Human genetics, Vol. 112, Issue 4, pp. 329-33, (2003) (PubMed).

Yotsumoto, Hashiguchi, Chen, Ohtake, Tomitaka, Akamatsu, Matsunaga, Shiraishi, Miura, Adachi, Kanzaki: "Novel mutations in GJB2 encoding connexin-26 in Japanese patients with keratitis-ichthyosis-deafness syndrome." dans: The British journal of dermatology, Vol. 148, Issue 4, pp. 649-53, (2003) (PubMed).

Uyguner, Tukel, Baykal, Eris, Emiroglu, Hafiz, Ghanbari, Baserer, Yuksel-Apak, Wollnik: "The novel R75Q mutation in the GJB2 gene causes autosomal dominant hearing loss and palmoplantar keratoderma in a Turkish family." dans: Clinical genetics, Vol. 62, Issue 4, pp. 306-9, (2002) (PubMed).

Abe, Kelley, Kimberling, Usami: "Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-->G mitochondrial mutation." dans: American journal of medical genetics, Vol. 103, Issue 4, pp. 334-8, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à GJB2

gap junction protein beta 2 L homeolog (gjb2.L), gap junction protein beta 2 (GJB2), gap junction protein, beta 2 (Gjb2), gap junction protein beta 2 (Gjb2), AI325222, Cnx26, connexin-26, cx26, Cx26, CX26, CXN-26, dfna3, DFNA3, dfna3a, DFNA3A, dfnb1, DFNB1, dfnb1a, DFNB1A, Gjb-2, GJB2, HID, KID, MGC53062, nsrd1, NSRD1, ppk, PPK

Protein level used designations for GJB2

  • gap junction protein, beta 2, 26kDa
  • connexin 26
  • connexin 29
  • gap junction membrane channel protein beta 6
  • gap junction protein, beta 2, 26kDa (connexin 26)
  • connexin-26
  • gap junction beta-2 protein
  • gap junction membrane channel protein beta 2
  • gap junction channel protein connexin 26
  • connexin26
  • gap junction protein beta 2
  • connexin 26 protein
  • cx26
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