Granulin Protéines
(Granulin (GRN))
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| Granulin Protein (GRN) (AA 1-247) (His tag) | Agrotis Segetum Granulosis Virus (AsGV) | Levure |
|
2.632,67 €
Voir le prix
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Trichoplusia ni Granulosis Virus (TnGV) | Levure |
|
2.634,50 €
Voir le prix
|
|
| Granulin Protein (GRN) (AA 1-247) (His tag) | Pieris brassicae Granulosis Virus (PbGV) | Levure |
|
2.632,67 €
Voir le prix
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Cydia pomonella Granulosis Virus (CpGV) | Levure |
|
2.634,50 €
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|
|
| Granulin Protein (GRN) (AA 18-588) (His tag) | Rat | Levure |
|
1.624,33 €
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|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Xestia c-nigrum Granulosis Virus (XnGV) | Levure |
|
2.634,50 €
Voir le prix
|
|
| Granulin Protein (GRN) (AA 1-248) (His tag) | Choristoneura fumiferana Granulovirus (CfGV) | Levure |
|
2.634,50 €
Voir le prix
|
|
| Granulin Protein (GRN) | Humain | – |
|
1.950,93 €
Voir le prix
|
|
| Granulin Protein (GRN) (His tag) | Humain | Escherichia coli (E. coli) |
|
503,00 €
Voir le prix
|
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Agrotis Segetum Granulosis Virus (AsGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Trichoplusia ni Granulosis Virus (TnGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Pieris brassicae Granulosis Virus (PbGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Cydia pomonella Granulosis Virus (CpGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Rat
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Xestia c-nigrum Granulosis Virus (XnGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Choristoneura fumiferana Granulovirus (CfGV)
- Hôte
- Levure
- Type Proteine
- Recombinant
- Pureté
- > 90 %
Protein
- SDS (SDS-PAGE: Application indiquée)
- WB (Western Blotting: Application indiquée)
- Imm (Immunogen: Application indiquée)
- ELISA (ELISA: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
Dernières publications pour nos Granulin Protéines
: "Tumor necrosis factor receptor 2/AKT and ERK signaling pathways contribute to the switch from fibroblasts to CAFs by progranulin in microenvironment of colorectal cancer." dans: Oncotarget, Vol. 8, Issue 16, pp. 26323-26333, (2018) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." dans: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." dans: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." dans: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
: "CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. ..." dans: EMBO molecular medicine, Vol. 10, Issue 12, (2018) (PubMed).
: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).
: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." dans: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).
: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." dans: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).
Pseudonymes pour Granulin Protéines
granulin precursor (GRN) Protéinesgranulin a (grna) Protéines
Granulins (grn) Protéines
granulin L homeolog (grn.L) Protéines
granulin (granulin) Protéines
granulin (ORF1 granulin) Protéines
granulin precursor (Grn) Protéines
granulin (Grn) Protéines
acrogranin Protéines
CLN11 Protéines
DKFZp459H066 Protéines
epithelin Protéines
GEP Protéines
GP88 Protéines
GRN Protéines
grn Protéines
MGC53354 Protéines
PCDGF Protéines
PEPI Protéines
PGRN Protéines
wu:fb11g12 Protéines
wu:fj18f05 Protéines
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