This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].
Dernières publications pour nos GSK3 alpha Protéines
Dunning, McGauran, Willén, Gouras, OConnell, Linse: "Direct High Affinity Interaction between Aβ42 and GSK3α Stimulates Hyperphosphorylation of Tau. A New Molecular Link in Alzheimer's Disease?" dans: ACS chemical neuroscience, Vol. 7, Issue 2, pp. 161-70, (2016) (PubMed).
Edwards: "Neisseria gonorrhoeae survival during primary human cervical epithelial cell infection requires nitric oxide and is augmented by progesterone." dans: Infection and immunity, Vol. 78, Issue 3, pp. 1202-13, (2010) (PubMed).