HGF Protéines
(Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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HGF
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
HGF
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Active
HGF
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 95 %
Inactive
HGF
Origine: Humain
Hôte: Human Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
HGF
Origine: Souris
Hôte: HEK-293 Cells
Recombinant
> 95 % by SDS-PAGE.
Active
HGF
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
ScA, IA, ADA, AM
HGF
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
ScA, IA, ADA, AM
HGF
Origine: Humain
Hôte: Hi-5 Cells
Recombinant
> 95 % as determined by SDS-PAGE and Coomassie blue staining
Func, STD, AbP, PI
Active
1 image
HGF
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
HGF
Origine: Humain
Hôte: Mammalian Cells
Recombinant
>95 % as determined by SDS-PAGE.
Func
Active
HGF
Origine: Humain
Hôte: Cellules d'insectes
Recombinant
> 98 % , as determined by Coomassie stained SDS-PAGE and HPLC analysis.
FACS
Active
Dernières publications pour nos HGF Protéines
: "Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation." dans: International journal of biological sciences, Vol. 16, Issue 14, pp. 2595-2611, (2020) (PubMed).
: "Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway." dans: Oncogene, (2016) (PubMed).
: "Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy." dans: Diabetes, Vol. 64, Issue 7, pp. 2581-92, (2015) (PubMed).
: "Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature." dans: Anticancer research, Vol. 35, Issue 5, pp. 2681-90, (2015) (PubMed).
: "PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model." dans: Biochimica et biophysica acta, Vol. 1852, Issue 11, pp. 2467-73, (2015) (PubMed).
: "Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 9, pp. 4055-67, (2015) (PubMed).
: "Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury." dans: European journal of biochemistry / FEBS, Vol. 193, Issue 2, pp. 375-81, (1990) (PubMed).
: "Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3200-4, (1990) (PubMed).
: "Blood vessel endothelium-directed tumor cell streaming in breast tumors requires the HGF/C-Met signaling pathway." dans: Oncogene, (2016) (PubMed).
: "Therapeutic Potential of Anti-Angiogenic Multitarget N,O-Sulfated E. Coli K5 Polysaccharide in Diabetic Retinopathy." dans: Diabetes, Vol. 64, Issue 7, pp. 2581-92, (2015) (PubMed).
: "Endothelial Cells Derived from Non-malignant Tissues Are of Limited Value as Models for Brain Tumor Vasculature." dans: Anticancer research, Vol. 35, Issue 5, pp. 2681-90, (2015) (PubMed).
: "PAX2 promoted prostate cancer cell invasion through transcriptional regulation of HGF in an in vitro model." dans: Biochimica et biophysica acta, Vol. 1852, Issue 11, pp. 2467-73, (2015) (PubMed).
: "Heat-shock protein 27 (HSP27, HSPB1) is up-regulated by MET kinase inhibitors and confers resistance to MET-targeted therapy." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 28, Issue 9, pp. 4055-67, (2015) (PubMed).
: "Primary structure of rat hepatocyte growth factor and induction of its mRNA during liver regeneration following hepatic injury." dans: European journal of biochemistry / FEBS, Vol. 193, Issue 2, pp. 375-81, (1990) (PubMed).
: "Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 8, pp. 3200-4, (1990) (PubMed).
Pseudonymes pour HGF Protéines
hepatocyte growth factor (HGF) Protéineshepatocyte growth factor (Hgf) Protéines
C230052L06Rik Protéines
DFNB39 Protéines
F-TCF Protéines
HGF Protéines
HGF/SF Protéines
HGFB Protéines
HPTA Protéines
NK1 Protéines
NK2 Protéines
SF Protéines
SF/HGF Protéines
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