IKZF1 Produits
(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
Catégories
This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].
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Catégories IKZF1 en vedette
IKZF1 Anticorps
High quality antibodies with extensive validation data.
IKZF1 Kits ELISA
Reliable ELISA kits for a wide range of species.
IKZF1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
IKZF1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN654180
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
N° du produit
ABIN7150361
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF, ChIP
Validations
- (4)
N° du produit
ABIN3015622
Quantité
100 μL
Fiche technique
Fiche technique
IKZF1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6967566
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1130242
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Chicken
Analytical Method
Validations
N° du produit
ABIN1130240
Quantité
96 tests
Fiche technique
Fiche technique
IKZF1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN7536631
Quantité
2 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123400
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093023
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits IKZF1
: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." dans: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).: "Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia." dans: The Journal of biological chemistry, Vol. 291, Issue 8, pp. 4004-18, (2016) (PubMed).
: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." dans: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).
: "Transcriptional regulation of the Ikzf1 locus." dans: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).
: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." dans: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).
: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." dans: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).
: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." dans: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).
: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." dans: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).
: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." dans: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).
: "Ikaros: a key regulator of haematopoiesis." dans: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à IKZF1
IKAROS family zinc finger 1 (IKZF1), IKAROS family zinc finger 1 (Ikzf1), IKAROS family zinc finger 1 (Ikaros) (ikzf1), IKAROS family zinc finger 1 (ikzf1), 5832432G11Rik, hIk-1, hik-1, hlk-1, Hs.54452, hs.54452, IK1, ik1, IKAROS, ikaros, Ikaros, ikzf1, LyF-1, LYF1, lyf1, MGC108252, mKIAA4227, PRO0758, pro0758, RGD1562979, Zfpn1a1, ZNFN1A1, znfn1a1, Znfn1a1Protein level used designations for IKZF1
- CLL-associated antigen KW-6
- DNA-binding protein Ikaros
- Ikaros (zinc finger protein)
- ikaros family zinc finger protein 1
- lymphoid transcription factor LyF-1
- zinc finger protein, subfamily 1A, 1 (Ikaros)
- Ikaros transcription factor
- KAROS family zinc finger 1 (Ikaros)
- IKAROS family zinc finger 1 (Ikaros)
- DNA-binding protein Ikaros-like
- zinc finger protein subfamily 1A, 1
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