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IKZF1 Produits

(IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))

Catégories

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. All isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homodimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and contain the nuclear localization signal, resulting in members with and without DNA-binding properties. Only few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and thought to function as dominant negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2011].

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Catégories IKZF1 en vedette

IKZF1 Anticorps

High quality antibodies with extensive validation data.

IKZF1 Kits ELISA

Reliable ELISA kits for a wide range of species.

IKZF1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

IKZF1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (1)
  • (4)
N° du produit ABIN654180
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
N° du produit ABIN7150361
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, ChIP
Validations
  • (4)
N° du produit ABIN3015622
Quantité 100 μL
Fiche technique Fiche technique

IKZF1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6967566
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1130242
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Chicken
Analytical Method
Validations
N° du produit ABIN1130240
Quantité 96 tests
Fiche technique Fiche technique

IKZF1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1307650
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123400
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3093023
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits IKZF1

Gao, Geng, Song, Lin, Liu, Cai, Cang: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." dans: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).

Wang, Song, Ding, Pan, Ge, Tan, Gowda, Sachdev, Muthusami, Ouyang, Lai, Francis, Morris, Abdel-Azim, Dorsam, Xiang, Payne, Dovat: "Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia." dans: The Journal of biological chemistry, Vol. 291, Issue 8, pp. 4004-18, (2016) (PubMed).

Iempridee, Reusch, Riching, Johannsen, Dovat, Kenney, Mertz: "Epstein-Barr virus utilizes Ikaros in regulating its latent-lytic switch in B cells." dans: Journal of virology, Vol. 88, Issue 9, pp. 4811-27, (2014) (PubMed).

Yoshida, Landhuis, Dose, Hazan, Zhang, Naito, Jackson, Wu, Perotti, Kaufmann, Gounari, Morgan, Georgopoulos: "Transcriptional regulation of the Ikzf1 locus." dans: Blood, Vol. 122, Issue 18, pp. 3149-59, (2013) (PubMed).

Zarnegar, Rothenberg: "Ikaros represses and activates PU.1 cell-type-specifically through the multifunctional Sfpi1 URE and a myeloid specific enhancer." dans: Oncogene, Vol. 31, Issue 43, pp. 4647-54, (2012) (PubMed).

Yeung, Chung, Guess, Bell, Leinwand: "Myh7b/miR-499 gene expression is transcriptionally regulated by MRFs and Eos." dans: Nucleic acids research, Vol. 40, Issue 15, pp. 7303-18, (2012) (PubMed).

Loeper, Asa, Ezzat: "Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation." dans: Cancer research, Vol. 68, Issue 10, pp. 3715-23, (2008) (PubMed).

Mullighan, Goorha, Radtke, Miller, Coustan-Smith, Dalton, Girtman, Mathew, Ma, Pounds, Su, Pui, Relling, Evans, Shurtleff, Downing: "Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia." dans: Nature, Vol. 446, Issue 7137, pp. 758-64, (2007) (PubMed).

Georgopoulos: "Haematopoietic cell-fate decisions, chromatin regulation and ikaros." dans: Nature reviews. Immunology, Vol. 2, Issue 3, pp. 162-74, (2002) (PubMed).

Westman, Mackay, Gell: "Ikaros: a key regulator of haematopoiesis." dans: The international journal of biochemistry & cell biology, Vol. 34, Issue 10, pp. 1304-7, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à IKZF1

IKAROS family zinc finger 1 (IKZF1), IKAROS family zinc finger 1 (Ikzf1), IKAROS family zinc finger 1 (Ikaros) (ikzf1), IKAROS family zinc finger 1 (ikzf1), 5832432G11Rik, hIk-1, hik-1, hlk-1, Hs.54452, hs.54452, IK1, ik1, IKAROS, ikaros, Ikaros, ikzf1, LyF-1, LYF1, lyf1, MGC108252, mKIAA4227, PRO0758, pro0758, RGD1562979, Zfpn1a1, ZNFN1A1, znfn1a1, Znfn1a1

Protein level used designations for IKZF1

  • CLL-associated antigen KW-6
  • DNA-binding protein Ikaros
  • Ikaros (zinc finger protein)
  • ikaros family zinc finger protein 1
  • lymphoid transcription factor LyF-1
  • zinc finger protein, subfamily 1A, 1 (Ikaros)
  • Ikaros transcription factor
  • KAROS family zinc finger 1 (Ikaros)
  • IKAROS family zinc finger 1 (Ikaros)
  • DNA-binding protein Ikaros-like
  • zinc finger protein subfamily 1A, 1
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