The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008].
Dernières publications pour nos Interleukin 17a Protéines
Yao, Weng, Zhang, Feng, Lin, Yao: "Interleukin-17A Acts to Maintain Neuropathic Pain Through Activation of CaMKII/CREB Signaling in Spinal Neurons." dans: Molecular neurobiology, Vol. 53, Issue 6, pp. 3914-3926, (2016) (PubMed).
Trinité, Ohlson, Voznesensky, Rana, Chan, Mahajan, Alster, Burke, Wodarz, Levy: "An HIV-1 replication pathway utilizing reverse transcription products that fail to integrate." dans: Journal of virology, Vol. 87, Issue 23, pp. 12701-20, (2013) (PubMed).
Arif, Moore, Marks, Bouckenooghe, Dayan, Planas, Vives-Pi, Powrie, Tree, Marchetti, Huang, Gurzov, Pujol-Borrell, Eizirik, Peakman: "Peripheral and islet interleukin-17 pathway activation characterizes human autoimmune diabetes and promotes cytokine-mediated β-cell death." dans: Diabetes, Vol. 60, Issue 8, pp. 2112-9, (2011) (PubMed).
Bérubé, Roussel, Nattagh, Rousseau et al.: "Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas ..." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22299-307, (2010) (PubMed).
Roussel, Houle, Chan, Yao, Bérubé, Olivenstein, Martin, Huot, Hamid, Ferri, Rousseau: "IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 8, pp. 4531-7, (2010) (PubMed).