Interleukin 17a Protein (AA 20-155) (His tag)

N° du produit ABIN7318648

Cette protéine Recombinant Interleukin 17a est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Interleukin 17a Protein (AA 20-155) (His tag) (ABIN7318648)

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Cell Culture (CC)

Pureté: > 98 % as determined by reducing SDS-PAGE.

Détail du produit

Attributs du protein: AA 20-155

Purification/Conjugué: Cette Interleukin 17a protéine est marqué à la His tag.

Fonction: Recombinant Human Interleukin-17A/IL-17A Protein

Séquence: Ile20-Ala155

Attributs du produit: Recombinant Human Interleukin-17A is produced by our E.coli expression system and the target gene encoding Ile20-Ala155 is expressed.

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 0.01 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Measure by its ability to induce IL-6 secretion in 3T3 cells. The ED₅₀ for this effect is <6 ng/mL.

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Lyophilized from sterile PBS, pH 8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Date de péremption: 12 months

Détail du antigène

Antigène: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Autre désignation: Interleukin-17A/IL-17A

Sujet: Cytotoxic T-lymphocyte-associated antigen,IL17A,CTLA-8,CTLA8,IL-17,IL-17A,IL17,Interleukin-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA 8,CTLA8,CTLA-8,CTLA8cytotoxic T-lymphocyte-associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL17,IL-17,IL17A,IL-17A,IL-17Acytotoxic T-lymphocyte-associated protein 8,IL-17CTLA-8,Cytotoxic T lymphocyte associated antigen 8,Cytotoxic T lymphocyte associated protein 8,Cytotoxic T lymphocyte associated serine esterase 8,IL 17A,Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8),Interleukin 17A,Interleukin17,Interleukin17A,OTTHUMP00000016597,OTTMUSP00000046003,Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Poids moléculaire:

Calculated MW: 16.5 kDa

Observed MW: 17 kDa

ID gène: 3605

UniProt: Q16552