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SensoLyte® 520 Neprilysin Activity Assay Kit

Act, FRET Fluorometric
N° du produit ABIN1882538
  • Antigène Voir toutes MME Kits
    MME (Membrane Metallo-Endopeptidase (MME))
    Méthode de détection
    Fluorometric
    Application
    Activation (Act), Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Marque
    SensoLyte®
    Attributs du produit
    The SensoLyte® 520 Neprilysin Assay Kit employs a novel internally quenched 5-FAM/QXL™ FRET substrate for the detection of neprilysin activity. The enzyme cleaves the FRET substrate into two separate fragments resulting in the release of 5-FAM fluorescence, which can be monitored at excitation /emission= 490/520 nm. The long wavelength fluorescence of 5-FAM is less interfered by the autofluorescence of components in biological samples and test compounds. The assay can detect as low as 0.78 ng/mL of active neprilysin.
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  • Commentaires

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Protect Components A abd B from light and moisture.
    Stock
    -80 °C
    Stockage commentaire
    Store all kit Components at -20 °C, except Component C, which should be stored at -80 °C.
  • Antigène
    MME (Membrane Metallo-Endopeptidase (MME))
    Autre désignation
    Neprilysin (MME Produits)
    Synonymes
    CALLA Kit, CD10 Kit, NEP Kit, SFE Kit, 6030454K05Rik Kit, C85356 Kit, Nep Kit, neprilysin Kit, membrane metalloendopeptidase Kit, membrane metallo endopeptidase Kit, membrane metallo-endopeptidase Kit, MME Kit, Mme Kit
    Classe de substances
    Chemical
    Sujet
    Neprilysin (NEP) is a transmembrane metallopeptidase normally expressed by a variety of tissues. It is also known as neutral endopeptidase, and enkephalinase. NEP cleaves peptides at the N-terminal side of hydrophobic amino acid residues and is responsible for the degradation and inactivation of a variety of physiological substrates. NEP is a major extracellular amyloid beta-peptide degrading enzyme in the brain and targeting NEP is considered a potential therapeutic strategy for the prevention and treatment of Alzheimer's disease. NEP has also been implicated in the pathogenesis of hypertension, diabetes, and cancer.
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