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SensoLyte® 520 Rat Renin Assay Kit

FRET Reactivité: Rat Fluorometric
N° du produit ABIN1882548
  • Antigène Voir toutes Renin (REN) Kits
    Renin (REN)
    Reactivité
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Méthode de détection
    Fluorometric
    Application
    Fluorescence Resonance Energy Transfer Microscopy (FRET)
    Marque
    SensoLyte®
    Attributs du produit
    The SensoLyte® 520 Rat Renin Assay Kit provides a convenient assay for high throughput screening of renin inhibitors and for continuous assay of renin activity using a 5-FAM/QXL™520 fluorescence resonance energy transfer (FRET) peptide. In the FRET peptide the fluorescence of 5-FAM is quenched by QXL™520. Upon cleavage into two separate fragments by renin, the fluorescence of 5-FAM is recovered, and can be monitored at excitation/emission = 490/520 nm.
    Top Product
    Discover our top product REN Kit ELISA
  • Commentaires

    FRET-based Assay Kit

    Restrictions
    For Research Use only
  • Conseil sur la manipulation
    Protect Components A and B from light and moisture.
    Stock
    -80 °C
    Stockage commentaire
    Store all kit components at -20 °C, except for Component C. Store Component C at -80 °C. Component D can be stored at room temperature for convenience
  • Matsushima, Furuuchi, Shirai, Nagai, Yokoyama, Nishida, Hirayama: "Effects of acute and chronic boysenberry intake on blood pressure and endothelial function in spontaneous hypertensive rats." dans: Journal of nutritional science and vitaminology, Vol. 60, Issue 1, pp. 43-51, (2014) (PubMed).

    Chelko, Schmiedt, Lewis, Lewis, Robertson: "A novel vascular clip design for the reliable induction of 2-kidney, 1-clip hypertension in the rat." dans: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 112, Issue 3, pp. 362-6, (2012) (PubMed).

    Shah, Dhar, El Zahraa Mohammed, Habtesion, Davies, Jover-Cobos, Macnaughtan, Sharma, Olde Damink, Mookerjee, Jalan: "Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression." dans: Journal of hepatology, Vol. 56, Issue 5, pp. 1047-53, (2012) (PubMed).

  • Antigène
    Renin (REN)
    Autre désignation
    Renin (REN Produits)
    Synonymes
    HNFJ2 Kit, RATRENAA Kit, RENAA Kit, Ren1 Kit, D19352 Kit, Ren Kit, Ren-1 Kit, Ren-A Kit, Ren1c Kit, Ren1d Kit, Rn-1 Kit, Rnr Kit, renin Kit, renin 1 structural Kit, REN Kit, Ren Kit, Ren1 Kit, ren Kit
    Sujet
    Renin, a highly specific aspartyl protease, cleaves angiotensinogen, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels leading to increased blood pressure. Discovery of new renin inhibitors for treatment of hypertension is a promising area of research.
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