IGFBP3 Kit ELISA

N° du produit ABIN2042507

Détail du produit IGFBP3 Kit ELISA

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 6-10000 pg/mL

Seuil minimal de détection: 6 pg/mL

Application: ELISA

Marque: BioAssay™

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Sensibilité: < 10 pg/mL

Ingrédients: 96-well plate pre-coated with anti-IGFBP-3, Mouse
Lyophilized recombinant IGFBP-3, Mouse standard, 10 ng/tube, 2Ea
Avidin-Biotin-Peroxidase Complex (ABC), 130 µL (1:100 dilution)
Sample diluent buffer, 30 mL
Antibody diluent buffer, 10 mL
ABC diluent buffer, 10 mL
TMB color developing agent, 10 mL
TMB stop solution, 10 mL

Information d'application

Plaque: Pre-coated

Protocole: Sandwich ELISA quantitative detection kit for Mouse IGFBP-3 in cell culture supernates and serum.Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers, and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene (IGFBP3) expression.1 Insulin-like growth factor-binding protein (IGFBP)-3, well characterized as the carrier of insulin-like growth factor (IGF), has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent, antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes.2 IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane, cytosol, or nuclear compartments and in the extrIGFBP-3llular matrix.3 IGFBP3 is also located on chromosome 7.4 The standard product used in this kit is recombinant mouse IGFBP-3, consisting of 270 amino acids with the molecular mass of 29.4kD. As a result of glycosylation, the molecular mass is 40-50kD.

Restrictions: For Research Use only

Stockage

Stock: 4 °C/-20 °C

Détail du antigène

Antigène: IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))

Autre désignation: IGFBP-3 (IGFBP3 Produits)

Synonymes: BP-53 Kit ELISA, IBP3 Kit ELISA, AI649005 Kit ELISA, IGFBP-3 Kit ELISA, IGgfbp3 Kit ELISA, IGF-BP3 Kit ELISA, zgc:91788 Kit ELISA, IGFBP3 Kit ELISA, igfbp3 Kit ELISA, insulin like growth factor binding protein 3 Kit ELISA, insulin-like growth factor binding protein 3 Kit ELISA, IGFBP3 Kit ELISA, Igfbp3 Kit ELISA, igfbp3 Kit ELISA, IGFBP-3 Kit ELISA, LOC100305016 Kit ELISA

ID gène: 3486

UniProt: B3KPF0

Pathways: Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding