IL-5 Kit ELISA
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- Antigène Voir toutes IL-5 (IL5) Kits ELISA
- IL-5 (IL5) (Interleukin 5 (IL5))
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Reactivité
- Souris
- Méthode de détection
- Colorimetric
- Type de méthode
- Sandwich ELISA
- Gamme de detection
- 0.02-1.0 ng/mL
- Seuil minimal de détection
- 0.02 ng/mL
- Application
- ELISA
- Type d'échantillon
- Cell Culture Supernatant, Serum, Plasma (heparin), Plasma (citrate), Plasma (EDTA)
- Analytical Method
- Quantitative
- Specificité
- Natural and recombinant Mouse IL-5 Ligand
- Sensibilité
- 7 pg/mL
- Matériel non inclus
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- Microplate reader.
- Pipettes and pipette tips.
- EP tube Deionized or distilled water.
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- Indications d'application
- Detection Wavelength: 450 nm
- Volume d'échantillon
- 20 μL
- Durée du test
- 3 h
- Plaque
- Pre-coated
- Restrictions
- For Research Use only
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- Stock
- 4 °C
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- Antigène Voir toutes IL-5 (IL5) Kits ELISA
- IL-5 (IL5) (Interleukin 5 (IL5))
- Autre désignation
- IL-5 (IL5 Produits)
- Synonymes
- EDF Kit ELISA, IL-5 Kit ELISA, TRF Kit ELISA, Il-5 Kit ELISA, IL5 Kit ELISA, interleukin 5 Kit ELISA, IL5 Kit ELISA, Il5 Kit ELISA
- Sujet
- Mouse interleukin 5 (mIL-5), also known as T-cell replacing factor, B-cell growth factor II, eosinophil differentiation factor and eosinophil colony stimulating factor, is a pleiotropic cytokine produced primarily by T cells (1-4). It supports the proliferation and differentiation of mouse, but not human, B cells, and enhances IgM, IgG1, IgA, and IgE secretion. IL-5 chemoattracts and enhances the survival and the effector functions of mature eosinophils and synergizes with various colony stimulating factors to increase eosinophil progenitor production and eosinophil expansion. Because of its diverse effects on eosinophils, IL-5 is strongly implicated in the pathogenesis of asthma and other hypereosinophilic inflammatory conditions (4-6). Mouse IL-5 cDNA encodes a 133 amino acid (aa) residue precursor protein containing a hydrophobic signal peptide that is cleaved to yield a 113 aa residue mature protein. Native mouse IL-5 is a disulfide-linked homodimeric 40-45 kDa glycoprotein with N- and O-linked carbohydrate chains. Mature human IL-5 is approximately 70 % identical at the amino acid level to mouse IL-5. Whereas mouse and human IL-5 are equally active on human cell lines, human IL-5 is much less active than mouse IL-5 in mouse cell assays (1-3). IL-5 is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes.
- Pathways
- Signalistation JAK/STAT, Positive Regulation of Peptide Hormone Secretion, Production of Molecular Mediator of Immune Response, Feeding Behaviour
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