Cardiotrophin 1 Kit ELISA

N° du produit ABIN5510574

Kit ELISA Souris Cardiotrophin 1, test Colorimetric pour la quantification de Souris Cardiotrophin 1.

Aperçu rapide pour Cardiotrophin 1 Kit ELISA (ABIN5510574)

Antigène: Cardiotrophin 1 (CTF1)

Épitope: AA 2-203

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Détail du produit Cardiotrophin 1 Kit ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Cardiotrophin-1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: E.coli, Immunogen sequence: S2-A203

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels in testis and brain. No expression in spleen.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: Cardiotrophin 1 (CTF1)

Autre désignation: Ctf1

Sujet:

Protein Function: Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.

Background: Cardiotrophin-1 (CT-1) is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), interleukin-6 (IL6), and interleukin-11 (IL11). And the CT-1 gene is mapped to 1p21-p13. The human CT-1 protein contains 201 amino acids and shares 80 % amino acid identity with the 203-amino acid mouse CT-1 sequence, however, unlike the mouse protein, human CT-1 has 2 rather than 1 cys and has no N-glycosylation site. Despite lacking a signal sequence, secreted CT-1 and mouse CT-1 induce cardiac myocyte hypertrophy in cell culture and bind to both mouse and human LIFR but not to OSMR. Furthermore, A 1.7-kb CT-1 transcript was detected at high levels in heart, skeletal muscle, prostate, and ovary. Low levels were detected in lung, kidney, pancreas, thymus, testis, and small intestine, with little or no expression detected in brain, placenta, spleen, colon, and peripheral blood leukocytes. And it was also observed strong expression in fetal lung and kidney.

Synonyms: Cardiotrophin-1, CT-1, Ctf1,

Full Gene Name: cardiotrophin 1

Cellular Localisation: Secreted.

UniProt: Q60753

Pathways: Signalistation JAK/STAT