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LDLR Kit ELISA

LDLR Reactivité: Humain AA 22-788 Colorimetric Sandwich ELISA
N° du produit ABIN5510704
  • Antigène Voir toutes LDLR Kits ELISA
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Épitope
    AA 22-788
    Reactivité
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human LDLR
    Marque
    PicoKine™
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO
    Immunogen sequence: A22-R788
    Réactivité croisée (Details)
    There is no detectable cross-reactivity with other relevant proteins.
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  • Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes LDLR Kits ELISA
    LDLR (Low Density Lipoprotein Receptor (LDLR))
    Autre désignation
    LDLR (LDLR Produits)
    Synonymes
    FH Kit ELISA, FHC Kit ELISA, LDLCQ2 Kit ELISA, Hlb301 Kit ELISA, LDLRA Kit ELISA, LDLA Kit ELISA, LDL receptor-2 Kit ELISA, fhc Kit ELISA, ldlcq2 Kit ELISA, ldlr Kit ELISA, ldlr2-a Kit ELISA, LDL receptor 1 Kit ELISA, ldlr-a Kit ELISA, ldlr-b Kit ELISA, low density lipoprotein receptor Kit ELISA, low density lipoprotein receptor a Kit ELISA, low density lipoprotein receptor S homeolog Kit ELISA, low density lipoprotein receptor L homeolog Kit ELISA, LDLR Kit ELISA, Ldlr Kit ELISA, ldlra Kit ELISA, ldlr.S Kit ELISA, ldlr.L Kit ELISA
    Sujet

    Protein Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.

    Background: The Low-Density Lipoprotein (LDL) Receptor is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. In humans, the LDL receptor protein is encoded by the LDLR gene. It belongs to the Low density lipoprotein receptor gene family. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

    Synonyms: Low-density lipoprotein receptor,LDL receptor,LDLR,

    Full Gene Name: Low-density lipoprotein receptor

    Cellular Localisation: Cell membrane, Single-pass type I membrane protein. Endomembrane system, Single-pass type I membrane protein. Membrane, clathrin-coated pit, Single-pass type I membrane protein. Golgi apparatus. Early endosome. Late endosome. Cell surface. Lysosome. Found distributed from the plasma membrane to intracellular compartments. Localizes to the Golgi apparatus, early and late endosomes/lysosomes and cell surface in the presence of PCSK9.
    UniProt
    P01130
    Pathways
    Hepatitis C, Lipid Metabolism
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