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IGFBP3 Kit ELISA

IGFBP3 Reactivité: Souris Colorimetric Sandwich ELISA 156 pg/mL - 10000 pg/mL Cell Culture Supernatant, Serum
N° du produit ABIN6719869
  • Antigène Voir toutes IGFBP3 Kits ELISA
    IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
    Reactivité
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Souris
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Gamme de detection
    156 pg/mL - 10000 pg/mL
    Seuil minimal de détection
    156 pg/mL
    Application
    ELISA
    Fonction
    Sandwich ELISA for Quantitative Detection of Antigen
    Type d'échantillon
    Cell Culture Supernatant, Serum
    Analytical Method
    Quantitative
    Attributs du produit

    Synonyms: Acid stable subunit of the 140 K IGF complex, Binding protein 29, Binding protein 53, BP 53, BP53, Growth hormone dependent binding protein, IBP 3, IBP3, IGF binding protein 3, IGFBP 3, Insulin Like Growth Factor Binding Protein 3

    Background: Insulin-like growth factor(IGF)-binding protein-3(IGFBP-3) is a major determinant of circulating levels of the IGFs and is clinically useful for the evaluation of GH deficiency and for predicting the response to GH treatment. The circulating level of IGFBP-3 is inversely related to the risk of several common cancers, and that antiproliferative agents such as antiestrogens and retinoids act in part by up-regulating IGFBP-3 gene(IGFBP3) expression. Insulin-like growth factor-binding protein(IGFBP)-3, well characterized as the carrier of insulin-like growth factor(IGF), has been reported to have intrinsic bioactivity that is independent of IGF binding. IGFBP-3 has an IGF-independent, antiproliferative effect in undifferentiated and early differentiated but not in terminally differentiated chondrocytes. IGFBP-3 possesses both growth-inhibitory and potentiating effects on cells that are independent of IGF action and are mediated through specific. IGFBP-3 binding proteins/receptors locate at the cell membrane, cytosol, or nuclear compartments and in the extrIGFBP-3llular matrix. IGFBP3 is also located on chromosome 7. The standard product used in this kit is recombinant mouse IGFBP-3, consisting of 270 amino acids with the molecular mass of 29.4 kDa. As a result of glycosylation, the molecular mass is 40-50KDa.

    Gene Name: IGFBP3

    Production: Natural and recombinant mouse IGFBP-3. There is no detectable cross-reactivity with other relevant proteins.

    Standard: Expression system for standard: NSO, Immunogen sequence: G28Q-K291

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  • Indications d'application

    Application Note: Useful in Sandwich ELISA for Quantitative Detection of Antigen. Aliquot 0.1 mL per well of the 10000pg/mL, 5000pg/mL, 2500pg/mL, 1250pg/mL, 625pg/mL, 313pg/mL, 156pg/mL mouse IGFBP-3 standard solutions into the precoated 96-well plate. Add 0.1 mL of the sample diluent buffer into the control well (Zero well). Add 0.1 mL of each properly diluted sample of mouse cell culture supernates or serum to each empty well. It is recommended that each mouse IGFBP-3 standard solution and each sample be measured in duplicate.

    ELISA Dilution: 156pg/mL-10000pg/mL

    Volume d'échantillon
    100 μL
    Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    RT,4 °C,-20 °C
    Stockage commentaire
    Store vials at 4°C prior to opening. Centrifuge product if not completely clear after standing at room temperature. This product is stable for 6 months at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage freeze at -20°C or below for 12 months. Avoid cycles of freezing and thawing.
  • Antigène Voir toutes IGFBP3 Kits ELISA
    IGFBP3 (Insulin-Like Growth Factor Binding Protein 3 (IGFBP3))
    Autre désignation
    IGFBP-3 (IGFBP3 Produits)
    Synonymes
    BP-53 Kit ELISA, IBP3 Kit ELISA, AI649005 Kit ELISA, IGFBP-3 Kit ELISA, IGgfbp3 Kit ELISA, IGF-BP3 Kit ELISA, zgc:91788 Kit ELISA, IGFBP3 Kit ELISA, igfbp3 Kit ELISA, insulin like growth factor binding protein 3 Kit ELISA, insulin-like growth factor binding protein 3 Kit ELISA, IGFBP3 Kit ELISA, Igfbp3 Kit ELISA, igfbp3 Kit ELISA, IGFBP-3 Kit ELISA, LOC100305016 Kit ELISA
    ID gène
    3486
    NCBI Accession
    NP_000589
    UniProt
    B3KPF0
    Pathways
    Myometrial Relaxation and Contraction, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Growth Factor Binding
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