PTH Kit ELISA

N° du produit ABIN996928

Kit ELISA PTH Chemical, Colorimetric test pour la quantification de Chemical PTH.

Aperçu rapide pour PTH Kit ELISA (ABIN996928)

Antigène: PTH (Parathyroid Hormone (PTH))

Reactivité: Chemical

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Type d'échantillon: Serum

Détail du produit PTH Kit ELISA

Fonction: Intact-PTH ELISA is intended for the quantitative determination of IntactPTH (Parathyroid Hormone) in human serum.

Analytical Method: Quantitative

Specificité: 100 %

Sensibilité: 1.72 pg/mL

Information d'application

Volume d'échantillon: 25 μL

Durée du test: 3 - 4 h

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Date de péremption: 12 months

Détail du antigène

Antigène: PTH (Parathyroid Hormone (PTH))

Sujet: PTH (Parathyroid hormone, Parathormone, Parathyrin) is biosynthesized in the parathyroid gland as a pre-proparathyroid hormone, a larger molecular precursor consisting of 115 amino acids. Following sequential intracellular cleavage of a 25-amino acid sequence, preproparathyroid hormone is converted to an intermediate, a 90-amino acid polypeptide, proparathyroid hormone. With additional proteolytic modification, proparathyroid hormone is then converted to parathyroid hormone, an 84 amino acid polypeptide. In healthy individuals, regulation of parathyroid hormone secretion normally occurs via a negative feedback action of serum calcium on the parathyroid glands. Intact PTH is biologically active and clears very rapidly from the circulation with a half-life of less than four minutes. PTH undergoes proteolysis in the parathyroid glands, but mostly peripherally, particularly in the liver but also in the kidneys and bone, to give N-terminal fragments and longer lived C-terminal and mid-region fragments. In subjects with renal insufficiency, C-terminal and mid-region PTH assays typically give elevated PTH results, as reflected by impaired renal clearance.

Pathways: cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process