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LAMC2 Produits

(Laminin, gamma 2 (LAMC2))
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain\; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011].

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Catégories LAMC2 en vedette

LAMC2 Anticorps

High quality antibodies with extensive validation data.

LAMC2 Kits ELISA

Reliable ELISA kits for a wide range of species.

LAMC2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

LAMC2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7442369
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7434659
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Rat
Application WB, ELISA, IHC (p)
Validations
  • (4)
N° du produit ABIN3187887
Quantité 100 μL
Fiche technique Fiche technique

LAMC2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (4)
  • (5)
N° du produit ABIN6730962
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1140006
Quantité 96 tests
Fiche technique Fiche technique

LAMC2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123715
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1309132
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
  • (1)
N° du produit ABIN3093443
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits LAMC2

Parikh, Puram, Faquin, Richmon, Emerick, Deschler, Varvares, Tirosh, Bernstein, Lin: "Immunohistochemical quantification of partial-EMT in oral cavity squamous cell carcinoma primary tumors is associated with nodal metastasis." dans: Oral oncology, Vol. 99, pp. 104458, (2019) (PubMed).

Teng, Wang, Ma, Zhang, Guo, Gu, Wang, Wang, Yue: "Prognostic significance of circulating laminin gamma2 for early-stage non-small-cell lung cancer." dans: OncoTargets and therapy, Vol. 9, pp. 4151-62, (2016) (PubMed).

Korbakis, Dimitromanolakis, Prassas, Davis, Barber, Reckamp, Blasutig, Diamandis: "Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer." dans: British journal of cancer, Vol. 113, Issue 3, pp. 484-91, (2015) (PubMed).

Chan, Prassas, Dimitromanolakis, Brand, Serra, Diamandis, Blasutig: "Validation of biomarkers that complement CA19.9 in detecting early pancreatic cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 20, Issue 22, pp. 5787-95, (2014) (PubMed).

Kosanam, Prassas, Chrystoja, Soleas, Chan, Dimitromanolakis, Blasutig, Rückert, Gruetzmann, Pilarsky, Maekawa, Brand, Diamandis: "Laminin, gamma 2 (LAMC2): a promising new putative pancreatic cancer biomarker identified by proteomic analysis of pancreatic adenocarcinoma tissues." dans: Molecular & cellular proteomics : MCP, Vol. 12, Issue 10, pp. 2820-32, (2013) (PubMed).

Liu, Tian, Jiang, Zhao, Guo, Li, Wang: "Aberrant expression of laminin γ2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma." dans: The Journal of surgical research, Vol. 186, Issue 1, pp. 150-6, (2013) (PubMed).

Amin, Janson, Sevéus, Miyazaki, Virtanen, Venge: "Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics." dans: Respiratory research, Vol. 6, pp. 110, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à LAMC2

laminin subunit gamma 2 (LAMC2), laminin, gamma 2 (Lamc2), laminin subunit gamma 2 (Lamc2), AA589349, B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMC2, LAMNB2

Protein level used designations for LAMC2

  • laminin 5 gamma 2 subunit
  • laminin subunit gamma-2
  • laminin-5 gamma 2
  • laminin, gamma 2
  • laminin, gamma 2-like
  • laminin 5 gamma 2
  • BM600-100kDa
  • CSF 140 kDa subunit
  • cell-scattering factor 140 kDa subunit
  • epiligrin subunit gamma
  • kalinin subunit gamma
  • ladsin 140 kDa subunit
  • laminin B2t chain
  • large adhesive scatter factor 140 kDa subunit
  • nicein subunit gamma
  • kalinin/nicein/epiligrin 100 kDa subunit
  • laminin gamma2 chain
  • laminin-5 subunit gamma
  • nicein, 100kD
  • nicein, 100kDa
  • lamimin, gamma 2
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