MSH alpha Produits
(MSH alpha)
Catégories
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
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Catégories MSH alpha en vedette
MSH alpha Kits ELISA
Reliable ELISA kits for a wide range of species.
MSH alpha recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN735323
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p)
Validations
N° du produit
ABIN735325
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB
Validations
N° du produit
ABIN735326
Quantité
100 μL
Fiche technique
Fiche technique
MSH alpha recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (6)
- (1)
N° du produit
ABIN6957888
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6957889
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6974470
Quantité
96 tests
Fiche technique
Fiche technique
MSH alpha recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Source
Synthetic
Validations
- (2)
N° du produit
ABIN1878818
Quantité
200 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MSH alpha
: "Alcohol Withdrawal and Proopiomelanocortin Neuropeptides in an Animal Model of Alcohol Dependence." dans: Neuropsychobiology, Vol. 78, Issue 3, pp. 118-127, (2020) (PubMed).: "Intermedin alleviates the inflammatory response and stabilizes the endothelial barrier in LPS-induced ARDS through the PI3K/Akt/eNOS signaling pathway." dans: International immunopharmacology, Vol. 88, pp. 106951, (2020) (PubMed).
: "Mechanisms of sustained long-term weight loss after RYGB: α-MSH is a key factor." dans: Neuropeptides, Vol. 69, pp. 60-65, (2019) (PubMed).
: "UVB-inhibited H19 activates melanogenesis by paracrine effects." dans: Experimental dermatology, Vol. 27, Issue 10, pp. 1120-1125, (2018) (PubMed).
: "Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses." dans: Cell stem cell, Vol. 22, Issue 5, pp. 698-712.e9, (2018) (PubMed).
: "Epigenetic alterations of the POMC promoter in tobacco dependence." dans: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, Vol. 28, Issue 7, pp. 875-879, (2018) (PubMed).
: "Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives." dans: Nature communications, Vol. 8, Issue 1, pp. 219, (2017) (PubMed).
: "Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity." dans: Endocrinology, Vol. 158, Issue 1, pp. 41-55, (2017) (PubMed).
: "Pharmacological induction of skin pigmentation unveils the neuroendocrine circuit regulated by light." dans: Pigment cell & melanoma research, Vol. 29, Issue 2, pp. 186-98, (2016) (PubMed).
: "Narrow-band ultraviolet B radiation induces the expression of β-endorphin in human skin in vivo." dans: Journal of photochemistry and photobiology. B, Biology, Vol. 155, pp. 104-8, (2016) (PubMed).
Synonymes et noms alternatifs relatifs à MSH alpha
proopiomelanocortin (POMC), STAM binding protein (STAMBP), pro-opiomelanocortin-alpha (Pomc), proopiomelanocortin (Pomc), ACTH, alpha-MSH, alphaMSH, AMSH, BE, Beta-LPH, beta-MSH, CLIP, Clip, Gamma-LPH, gamma-MSH, LPH, MSH, NPP, Npp, POC, Pomc-1, Pomc1, Pomc2Protein level used designations for MSH alpha
- adrenocorticotropic hormone
- adrenocorticotropin
- alpha-MSH
- alpha-melanocyte-stimulating hormone
- beta-LPH
- beta-MSH
- beta-endorphin
- beta-melanocyte-stimulating hormone
- corticotropin-like intermediary peptide
- corticotropin-lipotropin
- gamma-LPH
- gamma-MSH
- lipotropin beta
- lipotropin gamma
- melanotropin alpha
- melanotropin beta
- melanotropin gamma
- met-enkephalin
- opiomelanocortin prepropeptide
- pro-ACTH-endorphin
- pro-opiomelanocortin
- proopiomelanocortin preproprotein
- STAM-binding protein
- associated molecule with the SH3 domain of STAM
- endosome-associated ubiquitin isopeptidase
- alpha-melanocyte stimulating hormone
- beta-lipotropin
- beta-melanocyte stimulating hormone
- proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
- adrenal corticotropic hormone
- pro-opiomelanocortin-alpha
- proopiomelanocortin, beta (endorphin, beta)
- proopoimelanocortin, beta (endorphin, beta)
- Corticotropin-lipotropin
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