NUDT1 Produits
(Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))
Catégories
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Catégories NUDT1 en vedette
NUDT1 Anticorps
High quality antibodies with extensive validation data.
NUDT1 Kits ELISA
Reliable ELISA kits for a wide range of species.
NUDT1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NUDT1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (3)
N° du produit
ABIN7142858
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (3)
N° du produit
ABIN518070
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN7256838
Quantité
200 μL
Fiche technique
Fiche technique
NUDT1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969035
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730563
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6226065
Quantité
96 tests
Fiche technique
Fiche technique
NUDT1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1313165
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124237
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN3088099
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits NUDT1
: "The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress." dans: Mutation research, Vol. 808, pp. 10-19, (2019) (PubMed).: "The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia." dans: BMC cancer, Vol. 18, Issue 1, pp. 1190, (2019) (PubMed).
: "Potent and specific MTH1 inhibitors targeting gastric cancer." dans: Cell death & disease, Vol. 10, Issue 6, pp. 434, (2019) (PubMed).
: "Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue." dans: DNA repair, pp. 102644, (2019) (PubMed).
: "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. ..." dans: Nature communications, Vol. 9, Issue 1, pp. 250, (2018) (PubMed).
: "Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway." dans: Journal of lipid research, Vol. 59, Issue 5, pp. 830-842, (2018) (PubMed).
: "Validating the concept of mutational signatures with isogenic cell models." dans: Nature communications, Vol. 9, Issue 1, pp. 1744, (2018) (PubMed).
: "hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia." dans: Oncogenesis, Vol. 5, Issue 12, pp. e275, (2016) (PubMed).
: "Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma." dans: International journal of hematology, Vol. 105, Issue 3, pp. 318-325, (2016) (PubMed).
: "MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways." dans: Oncogene, Vol. 34, Issue 20, pp. 2586-96, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à NUDT1
7,8-dihydro-8-oxoguanine triphosphatase (mth1), 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498), nudix hydrolase 1 (nudt1), 7,8-dihydro-8-oxoguanine triphosphatase (8odp), nudix hydrolase 1 (NUDT1), nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1), nudix hydrolase 1 (Nudt1), MTH1, Mth1, mutT, nudT1Protein level used designations for NUDT1
- 7,8-dihydro-8-oxoguanine triphosphatase
- 2-hydroxy-dATP diphosphatase
- 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
- 8-oxo-7,8-dihydroguanosine triphosphatase
- 8-oxo-dGTPase
- mutT human homolog 1
- nucleoside diphosphate-linked moiety X motif 1
- nucleoside diphosphate-linked moiety X-type motif 1
- nudix motif 1
- 8-oxo-7,8-dihydro-2'-dGTPase
- mutT human homolog (8-oxo-dGTPase)
- nudix-type motif 1
Avez-vous cherché autre chose?
- NUDL
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 4
- Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 3
- NudE Neurodevelopment Protein 1
- NUDCD3
- NUDCD2
- NUDCD1
- NUDC
- Nucleotide Binding Protein 1
- Nucleostemin
- Nucleosome Assembly Protein 1-Like 4
- Nucleosome Assembly Protein 1-Like 1
- Nucleoside Monophosphate Kinase
- Nucleoside Diphosphate Kinase
- Nucleolin
- Nucleolar Protein 6
- Nucleolar Protein 1
- Nucleolar Complex Associated 4 Homolog
- Nucleolar and Spindle Associated Protein 1
- Nucleobindin 1
Vous êtes ici:
