NUDT1 Protein (AA 1-156) (His tag)

N° du produit ABIN667233

Détail du produit

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Type de proteíne: Recombinant

Attributs du protein: AA 1-156

Origine: Humain

Source: Escherichia coli (E. coli)

Purification/Conjugué: Cette NUDT1 protéine est marqué à la His tag.

Application: SDS-PAGE (SDS)

Attributs du produit: NUDT1, 1-156aa, Human, His tag, E.coli

Pureté: > 95 % by SDS - PAGE

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1mg/ml (determined by BCA)

Buffer: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol, 2mM DTT, 100mM NaCl

Stock: 4 °C

Détail du antigène

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Autre désignation: NUDT1 (NUDT1 Produits)

Synonymes: mutT Protein, nudT1 Protein, MTH1 Protein, Mth1 Protein, 7,8-dihydro-8-oxoguanine triphosphatase Protein, nudix hydrolase 1 Protein, nudix (nucleoside diphosphate linked moiety X)-type motif 1 Protein, mth1 Protein, Tsp_07498 Protein, nudt1 Protein, 8odp Protein, NUDT1 Protein, Nudt1 Protein

Sujet: NUDT1 is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. It is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. And this protein expressed at much higher levels in proliferating cells than in resting cells. Recombinant human NUDT1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. Synonyms: MTH1, 8-oxo-dGTPase, Nudix motif 1, 7,8-dihydro-8-oxoguanine triphosphatase. NCBI no.: NP_945191

Poids moléculaire: 20.1kDa (176aa), confirmed by MALDI-TOF