A synthetic peptide for use as a blocking control in assays to test for specificity of Rest antibody, Alternative Names: Rest control peptide, Rest antibody Blocking Peptide, Anti-Rest Blocking Peptide, RE1-silencing transcription factor Blocking Peptide, 2610008J04Rik Blocking Peptide, AA407358 Blocking Peptide, MGC150099 Blocking Peptide, NRSF Blocking Peptide
REST
Reactivité: Humain, Souris, Rat
Hôte: Synthetic
BP, WB, ICo, IDe
Indications d'application
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
REST
(RE1-Silencing Transcription Factor (REST))
Sujet
Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.