A synthetic peptide for use as a blocking control in assays to test for specificity of CD8 A antibody, Alternative Names: CD8A control peptide, CD8A antibody Blocking Peptide, Anti-CD8A Blocking Peptide, CD8a molecule Blocking Peptide, CD8 Blocking Peptide, Leu2 Blocking Peptide, MAL Blocking Peptide, p32 Blocking Peptide, CD8A, CD-8A, CDA 8, CD-8A Blocking Peptide, CD 8A Blocking Peptide
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene.