A synthetic peptide for use as a blocking control in assays to test for specificity of TIMELESS antibody, Alternative Names: TIMELESS control peptide, TIMELESS antibody Blocking Peptide, Anti-TIMELESS Blocking Peptide, timeless homolog, Drosophila Blocking Peptide
TIMELESS
Reactivité: Souris, Rat
Hôte: Synthetic
BP, WB, ICo, IDe
Indications d'application
Optimal conditions should be determined by the investigator
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 µL of distilled water for a final peptide concentration is 1 mg/mL.
Buffer
PBS
Conseil sur la manipulation
Avoid repeated freeze/thaw cycles.
Stock
-20 °C
Stockage commentaire
Store at -20 °C long term.
Antigène
TIMELESS
(Timeless Homolog (TIMELESS))
Sujet
The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.