APOBEC1 Complementation Factor (A1CF) (N-Term) Peptide
A1CF
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN972679
Aperçu rapide pour APOBEC1 Complementation Factor (A1CF) (N-Term) Peptide (ABIN972679)
Antigène
A1CF
(APOBEC1 Complementation Factor (A1CF))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-A1CF antibody (Catalog #: ARP41109_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- A1CF (APOBEC1 Complementation Factor (A1CF))
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Sujet
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Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. A1CF has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.Mammalian apolipoprotein B mRNA undergoes site-specific C to U deamination, which is mediated by a multi-component enzyme complex containing a minimal core composed of APOBEC-1 and a complementation factor encoded by this gene. The gene product has three non-identical RNA recognition motifs and belongs to the hnRNP R family of RNA-binding proteins. It has been proposed that this complementation factor functions as an RNA-binding subunit and docks APOBEC-1 to deaminate the upstream cytidine. Studies suggest that the protein may also be involved in other RNA editing or RNA processing events. Alternative splicing occurs at this locus and three full-length transcript variants, encoding three distinct isoforms, have been described. Additional splicing has been observed but the full-length nature of these variants has not been determined.
Alias Symbols: ACF, ACF64, ACF65, APOBEC1CF, ASP, MGC163391, RP11-564C4.2
Protein Interaction Partner: APOBEC1,CELF2,KHSRP,SYNCRIP,TNPO2,APOBEC1,CELF2,KHSRP,SYNCRIP,TNPO2
Protein Size: 594 -
Poids moléculaire
- 65 kDa
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ID gène
- 29974
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NCBI Accession
- NM_138933, NP_620311
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UniProt
- Q9NQ94
Antigène
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