Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) (N-Term) Peptide
ADRBK1
Reactivité: Humain
Hôte: Synthetic
BP, WB
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- Antigène Tous les produits GRK2 (ADRBK1)
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- Protein Region
- N-Term
- Origine
- Humain
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Séquence
- PEPSIRSVMQ KYLEDRGEVT FEKIFSQKLG YLLFRDFCLN HLEEARPLVE
- Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-ADRBK1 Antibody(ARP51965_P050),. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
- Purification
- Purified
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- Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Concentration
- 1 mg/mL
- Buffer
- Final peptide concentration is 1 mg/mL in PBS.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Antigène
- GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
- Synonymes
- Adrbk-1 Peptide, Bark-1 Peptide, GRK2 Peptide, betaARK1 Peptide, BARK1 Peptide, BETA-ARK1 Peptide, GRK-2 Peptide, Grk2 Peptide, beta-adrenergic receptor kinase 1 Peptide, G protein-coupled receptor kinase 2 Peptide, Tsp_00497 Peptide, grk2 Peptide, Grk2 Peptide, GRK2 Peptide
- Sujet
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The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Alias Symbols: BARK1, BETA-ARK1, FLJ16718, GRK2
Protein Interaction Partner: PEBP1,ADRA2A,AGTR1,AKAP12,ARRB1,BDKRB2,CAPN2,CAV1,CCR4,CCR5,EGF,EGFR,FPR1,FSHR,GIT1,GIT2,GNAQ,GRM1,MAPK3,MC4R,MDM2,NCS1,OPRD1,PDC,PDCL,PDE6G,PEBP1,PIK3CG,PRKACA,PRKCA,PRKCB,PRKCD,PRKCG,RCVRN,RHO,RPLP2,SNCA,SRC,TPM2,ADRB2,AGTR1,CAV1,CCR4,EDNRB,FSHR,GIT1,GI
Protein Size: 689 - Poids moléculaire
- 79 kDa
- ID gène
- 156
- NCBI Accession
- NM_001619, NP_001610
- UniProt
- P25098
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