This is a synthetic peptide designed for use in combination with anti-Bnip3l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
BNIP3L
Reactivité: Humain
Hôte: Synthetic
BP, BI
Sodium azide
Indications d'application
Each Investigator should determine their own optimal working dilution for specific applications.
Restrictions
For Research Use only
Format
Lyophilized
Reconstitution
Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
Concentration
1 mg/mL
Buffer
Final peptide concentration is 1 mg/mL in PBS.
Conseil sur la manipulation
Avoid repeated freeze-thaw cycles.
Stock
-20 °C
Stockage commentaire
For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
Antigène
BNIP3L/NIX (BNIP3L)
(BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))
Synonymes
BNIP3a Peptide, NIX Peptide, NIP3 Peptide, Nix Peptide, Nip3 Peptide, C86132 Peptide, D14Ertd719e Peptide, Nip3L Peptide, bnip3l Peptide, nip3 Peptide, zgc:110478 Peptide, bnip3l2 Peptide, wu:fb52b03 Peptide, wu:fc02h04 Peptide, BCL2 interacting protein 3 like Peptide, BCL2 interacting protein 3 Peptide, BCL2/adenovirus E1B interacting protein 3 Peptide, BCL2/adenovirus E1B interacting protein 3-like Peptide, BCL2/adenovirus E1B interacting protein 3-like b Peptide, BCL2/adenovirus E1B interacting protein 3-like a Peptide, BNIP3L Peptide, BNIP3 Peptide, Bnip3l Peptide, Bnip3 Peptide, bnip3lb Peptide, bnip3la Peptide
Sujet
Bnip3l induces apoptosis. It interacts with viral and cellular anti-apoptosis proteins. It can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. It inhibits apoptosis induced by BNIP3. It is involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. Bnip3l may function as a tumor suppressor.