Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide
CHRNB2
Reactivité: Humain
Hôte: Synthetic
BP, WB, IHC
N° du produit ABIN974959
150,78 €
Plus frais de livraison 40,00 € et TVA
100 μg
Destination:
France
Envoi sous 15 à 22 jours ouvrables
Aperçu rapide pour Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) Peptide (ABIN974959)
Antigène
CHRNB2
(Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-CHRNB2 antibody (Catalog #: ARP34970_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2) peptide
CHRNB2 Reactivité: Humain, Boeuf (Vache), Chien, Souris, Porc, Rat Hôte: Synthetic BP, Imm
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- CHRNB2 (Cholinergic Receptor, Nicotinic, beta 2 (Neuronal) (CHRNB2))
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Sujet
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Mutations in nAChRs are found in a rare form of nocturnal frontal lobe epilepsy . Previously, some nAChR mutations have been described that are associated with additional neurological features such as psychiatric disorders or cognitive defects. A new CHRNB2 mutation located in transmembrane region 3 (M3), outside the known ADNFLE mutation cluster. The CHRNB2 mutation I312M, which occurred de novo in twins, markedly increases the receptor's sensitivity to acetylcholine. Phenotypically, the mutation is associated not only with typical ADNFLE, but also with distinct deficits in memory. The cognitive problems are most obvious in tasks requiring the organization and storage of verbal information.
Alias Symbols: EFNL3, nAChRB2
Protein Interaction Partner: CHRNA4,CHRNA2,CHRNA4,CRELD2
Protein Size: 502 -
Poids moléculaire
- 57 kDa
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ID gène
- 1141
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NCBI Accession
- NM_000748, NP_000739
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UniProt
- P17787
Antigène
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