TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term) Peptide
TAB1
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN979778
Aperçu rapide pour TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (N-Term) Peptide (ABIN979778)
Antigène
TAB1
(TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-MAP3K7IP1 antibody (Catalog #: ARP53182_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- TAB1 (TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1))
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Sujet
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The specific function of the protein remains unknown.The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Alias Symbols: 3'-Tab1, MGC57664, TAB1, MAP3K7IP1
Protein Interaction Partner: MAP3K7,MAPK14,XIAP,BMPR1A,MAP3K7,MAPK11,MAPK14,NR2C2,SMAD6,SMAD7,TAB2,TAB3,TRAF2,TRAF6,XIAP,YWHAG,MAP3K7,MAPK14,Rrp1b,SMAD6,SMAD7,TAB2,TAB3,TRAF2,TRAF6,XIAP,ZMYND11
Protein Size: 462 -
Poids moléculaire
- 50 kDa
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ID gène
- 10454
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NCBI Accession
- NM_153497, NP_705717
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UniProt
- Q8IZW2
Antigène
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