RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide
REST
Reactivité: Souris
Hôte: Synthetic
BP, WB
N° du produit ABIN982857
Aperçu rapide pour RE1-Silencing Transcription Factor (REST) (Middle Region) Peptide (ABIN982857)
Antigène
REST
(RE1-Silencing Transcription Factor (REST))
Origine
Souris
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Protein Region
- Middle Region
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Séquence
- ANMGMALTND MYDLHELSKA ELAAPQLIML ANVALTGEAS GSCCDYLVGE
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-Rest Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- REST (RE1-Silencing Transcription Factor (REST))
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Sujet
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Rest is a transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Rest restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Rest mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Alias Symbols: 2610008J04Rik, AA407358, MGC150099, NRSF
Protein Size: 1082 -
Poids moléculaire
- 118 kDa
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ID gène
- 19712
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NCBI Accession
- NM_011263, NP_035393
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UniProt
- Q8VIG1
Antigène
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