Runt-Related Transcription Factor 2 (RUNX2) Peptide
RUNX2
Reactivité: Humain
Hôte: Synthetic
BP, WB
N° du produit ABIN983330
Aperçu rapide pour Runt-Related Transcription Factor 2 (RUNX2) Peptide (ABIN983330)
Antigène
RUNX2
(Runt-Related Transcription Factor 2 (RUNX2))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Western Blotting (WB)
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-RUNX2 antibody (Catalog #: ARP36678_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
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Sujet
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RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.
Alias Symbols: CCD, AML3, CCD1, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2A1, PEBP2A2, PEBP2aA, PEBP2aA1
Protein Interaction Partner: RB1,AR,AXIN1,CBFB,CCNB1,CDK1,CEBPB,DVL2,EP300,ETS1,FOS,HDAC3,HDAC4,HDAC6,JUN,LEF1,MAP3K4,MSX2,MYST4,PRKCD,RB1,SMAD2,SMAD3,SMAD6,TAF1A,UBTF,XRCC5,XRCC6,YAP1,ETS1,FOS,HDAC3,HDAC4,HDAC6,JUN,LEF1,MSX2,MYST4,SMAD1,SMAD2,SMAD3,SMAD5,STUB1,THOC4,TLE1,YAP1
Protein Size: 521 -
Poids moléculaire
- 57 kDa
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ID gène
- 860
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NCBI Accession
- NM_001024630, NP_001019801
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UniProt
- Q13950
Antigène
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