Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) Peptide
STAT5B
Reactivité: Humain
Hôte: Synthetic
BP, IHC, WB
N° du produit ABIN984535
Aperçu rapide pour Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) Peptide (ABIN984535)
Antigène
STAT5B
(Signal Transducer and Activator of Transcription 5B (STAT5B))
Origine
Humain
Source
Synthetic
Application
Blocking Peptide (BP), Immunohistochemistry (IHC), Western Blotting (WB)
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Protein Region
- N-Term
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Attributs du produit
- This is a synthetic peptide designed for use in combination with anti-STAT5B antibody (Catalog #: ARP39000_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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Purification
- Purified
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Indications d'application
- Each Investigator should determine their own optimal working dilution for specific applications.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
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Concentration
- 1 mg/mL
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Buffer
- Final peptide concentration is 1 mg/mL in PBS.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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Sujet
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The protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: STAT5
Protein Interaction Partner: NMI,STAT5B,CBL,CD247,CENPJ,CRK,CRKL,CTLA4,CXCR4,EGFR,ELP2,EP300,EPOR,ERBB4,ETS1,ETS2,GHR,IL2RA,IL2RB,IL7R,INSR,JAK2,KIT,MAPK1,NCOR2,NMI,NR3C1,PDGFRA,PDGFRB,POU2F1,PPP2CA,PTPN1,PTPN11,PTPN2,PTPN6,RARA,SHC1,SRC,STAP2,STAT1,STAT3,STAT5A,STAT5B,TEK,CCR5,CD247,EGFR,ELP2,GHR,IL2RB,JAK1,JAK2,JAK3,NMI,NR3C1,PTPN1,PTPN11,PTPN6,SHC1
Protein Size: 787 -
Poids moléculaire
- 90 kDa
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ID gène
- 6777
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NCBI Accession
- NM_012448, NP_036580
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UniProt
- P51692
Antigène
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