Phosphatidylinositol Binding clathrin Assembly Protein Produits
(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
Catégories
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
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Catégories Phosphatidylinositol Binding clathrin Assembly Protein en vedette
Phosphatidylinositol Binding clathrin Assembly Protein Anticorps
High quality antibodies with extensive validation data.
Phosphatidylinositol Binding clathrin Assembly Protein Kits ELISA
Reliable ELISA kits for a wide range of species.
Phosphatidylinositol Binding clathrin Assembly Protein Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Phosphatidylinositol Binding clathrin Assembly Protein recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7163230
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (2)
N° du produit
ABIN1501903
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validations
- (1)
N° du produit
ABIN1385889
Quantité
100 μL
Fiche technique
Fiche technique
Phosphatidylinositol Binding clathrin Assembly Protein recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6958523
Quantité
96 tests
Fiche technique
Fiche technique
Phosphatidylinositol Binding clathrin Assembly Protein recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1315001
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3086159
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3135908
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits Phosphatidylinositol Binding clathrin Assembly Protein
: "Cellular protein profiles altered by PRRSV infection of porcine monocytes-derived dendritic cells." dans: Veterinary microbiology, Vol. 228, pp. 134-142, (2019) (PubMed).: "Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice." dans: Journal of biomedical science, Vol. 23, Issue 1, pp. 49, (2016) (PubMed).
: "Decreasing the expression of PICALM reduces endocytosis and the activity of β-secretase: implications for Alzheimer's disease." dans: BMC neuroscience, Vol. 17, Issue 1, pp. 50, (2016) (PubMed).
: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." dans: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).
: "Modulation of PICALM Levels Perturbs Cellular Cholesterol Homeostasis." dans: PLoS ONE, Vol. 10, Issue 6, pp. e0129776, (2015) (PubMed).
: "Lysosomal network proteins as potential novel CSF biomarkers for Alzheimer's disease." dans: Neuromolecular medicine, Vol. 16, Issue 1, pp. 150-60, (2014) (PubMed).
: "Distribution and expression of picalm in Alzheimer disease." dans: Journal of neuropathology and experimental neurology, Vol. 69, Issue 10, pp. 1071-7, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à Phosphatidylinositol Binding clathrin Assembly Protein
leucine aminopeptidase 3 (LAP3), phosphatidylinositol binding clathrin assembly protein (PICALM), phosphatidylinositol binding clathrin assembly protein (Picalm), si:ch211-200p22.4 (si:ch211-200p22.4), CALM, Calm, CLTH, fit-1, fit1, LAP, LAP-3, mKIAA4114, PAP180, PEPSProtein level used designations for Phosphatidylinositol Binding clathrin Assembly Protein
- LAP
- cytosol aminopeptidase
- leucyl aminopeptidase
- peptidase S
- proline aminopeptidase
- prolyl aminopeptidase
- clathrin assembly lymphoid myeloid leukemia protein
- phosphatidylinositol-binding clathrin assembly protein
- clathrin assembly lymphoid myeloid leukemia
- clathrin-assembly lymphoid leukemia protein
- clathrin-assembly lymphoid myeloid leukemia protein
- rCALM
- uncharacterized protein LOC772071
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- Phosphoglycerate Kinase
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- Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide
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- Phospholamban
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