The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
Gegunde, Alfonso, Alvariño, Alonso, Botana: "Cyclophilins A, B, and C Role in Human T Lymphocytes Upon Inflammatory Conditions." dans: Frontiers in immunology, Vol. 12, pp. 609196, (2021) (PubMed).
Ray, Sullenger, White: "Further characterization of the target of a potential aptamer biomarker for pancreatic cancer: cyclophilin B and its posttranslational modifications." dans: Nucleic acid therapeutics, Vol. 23, Issue 6, pp. 435-42, (2013) (PubMed).
Pseudonymes pour PPIB Protéines
peptidylprolyl isomerase B (ppib) Protéines peptidylprolyl isomerase B (PPIB) Protéines peptidylprolyl isomerase B (Ppib) Protéines peptidylprolyl isomerase B (CC1G_03223) Protéines peptidylprolyl isomerase B (cyclophilin B) (Ppib) Protéines peptidylprolyl isomerase B L homeolog (ppib.L) Protéines peptidylprolyl isomerase B (cyclophilin B) (PPIB) Protéines peptidylprolyl isomerase B (cyclophilin B) (ppib) Protéines AA408962 Protéines AA553318 Protéines ACYPI004891 Protéines AI844835 Protéines cb87 Protéines Cphn-2 Protéines Cphn2 Protéines CyP-20b Protéines cyp-s1 Protéines CYP-S1 Protéines cypb Protéines CypB Protéines CYPB Protéines OI9 Protéines PPIB Protéines Ppib Protéines sb:cb87 Protéines scylp Protéines Scylp Protéines SCYLP Protéines wu:fa97f08 Protéines zgc:73214 Protéines zgc:86796 Protéines