The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008].
Nguyen, Stevens, Kohr, Steenbergen, Sack, Murphy: "Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore." dans: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40184-92, (2011) (PubMed).
McGee, Baines: "Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death." dans: The Biochemical journal, Vol. 433, Issue 1, pp. 119-25, (2010) (PubMed).
Pseudonymes pour PPID Protéines
peptidylprolyl isomerase D (PPID) Protéines peptidylprolyl isomerase D (Ppid) Protéines peptidylprolyl isomerase D (ppid) Protéines peptidylprolyl isomerase D (cyclophilin D) (Ppid) Protéines peptidylprolyl isomerase D (cyclophilin D) S homeolog (ppid.S) Protéines 4930564J03Rik Protéines CYP-40 Protéines Cyp-40 Protéines cyp-40 Protéines CYPD Protéines CypD Protéines cypd Protéines PPID Protéines Ppidl Protéines Ppif Protéines wu:fb18b07 Protéines zgc:86711 Protéines