Proprotein Convertase Subtilisin/kexin Type 9 Protéines
(Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9))
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008].
| Catalog no. | Produit | Reactivité | Hôte / Clonalité | Application | Prix et délai de livraison |
|---|---|---|---|---|---|
| PCSK9 Protein (AA 35-694) (His tag) | Souris | HEK-293 Cells |
|
347,53 €
Voir le prix
|
|
| PCSK9 Protein (AA 151-811) (His tag) | Cynomolgus | HEK-293 Cells |
|
347,53 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692) (His tag) | Humain | HEK-293 Cells |
|
516,35 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692) (His tag,AVI tag,Biotin) | Humain | HEK-293 Cells |
|
1.965,35 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692) (Fc Tag) | Humain | HEK-293 Cells |
|
817,38 €
Voir le prix
|
|
| PCSK9 Protein (His tag) | Souris | HEK-293 Cells |
|
866,00 €
Voir le prix
|
|
| PCSK9 Protein (His tag) | Rat | HEK-293 Cells |
|
443,60 €
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|
|
| PCSK9 Protein (AA 1-678) (GST tag) | Humain | Wheat germ |
|
624,00 €
Voir le prix
|
|
| PCSK9 Protein (AA 35-155, AA 156-694) (His tag) | Souris | HEK-293 Cells |
|
479,60 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692) (Fc Tag) | Humain | HEK-293 Cells |
|
434,70 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-227) (His-IF2DI Tag) | Humain | Escherichia coli (E. coli) |
|
476,92 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692) (His tag) | Humain | Human Cells |
|
395,04 €
Voir le prix
|
|
| PCSK9 Protein (AA 35-692) (His tag) | Souris | Human Cells |
|
608,79 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-152, AA 153-692) (His tag) | Macaque rhésus | Human Cells |
|
608,79 €
Voir le prix
|
|
| PCSK9 Protein (His tag) | Humain | HEK-293 Cells |
|
340,00 €
Voir le prix
|
|
| PCSK9 Protein (AA 35-694) (His tag) | Souris | Mammalian Cells |
|
635,60 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-692, D374Y) (His tag) | Humain | HEK-293 Cells |
|
287,60 €
Voir le prix
|
|
| PCSK9 Protein (AA 1-692) (His tag) | Humain | HEK-293 Cells |
|
1.778,00 €
Voir le prix
|
|
| PCSK9 Protein (AA 1-691) (His tag) | Rat | HEK-293 Cells |
|
635,60 €
Voir le prix
|
|
| PCSK9 Protein (AA 31-152, AA 153-692) (His tag) | Macaca nemestrina | HEK-293 Cells |
|
479,60 €
Voir le prix
|
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- SPR (Surface Plasmon Resonance: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- SEC-HPLC (Size-exclusion chromatography-High Pressure Liquid Chromatography: Image de validation disponible)
- SPR (Surface Plasmon Resonance: Image de validation disponible)
- Origine
- Cynomolgus
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
10 références - Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >97 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Bind (Binding Studies: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >92 % as determined by reduced SDS-PAGE.
- Activité biologique
- Active
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- AM (Affinity Measurement: Application indiquée)
- ADA (Antibody Drug Assay: Application indiquée)
- IA (Immunoassay: Application indiquée)
- ScA (Screening Assay: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Protein
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Image de validation disponible)
- ELISA (ELISA: Application indiquée)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 97 % as determined by reducing SDS-PAGE.
- Activité biologique
- Active
Protein
- AbP (Antibody Production: Application indiquée)
- ELISA (ELISA: Application indiquée)
- PAr (Protein Array: Application indiquée)
- WB (Western Blotting: Application indiquée)
- Origine
- Humain
- Hôte
- Wheat germ
- Type Proteine
- Recombinant
Protein
- WB (Western Blotting: Image de validation disponible)
- Origine
- Souris
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- SDS (SDS-PAGE: Image de validation disponible)
- ELISA (ELISA: Image de validation disponible)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- >90 % as determined by SDS-PAGE.
- Activité biologique
- Active
Protein
- WB (Western Blotting: Application indiquée)
- ELISA (ELISA: Application indiquée)
- Origine
- Humain
- Hôte
- Escherichia coli (E. coli)
- Type Proteine
- Recombinant
- Pureté
- Greater than 90 % as determined by SDS-PAGE.
Protein
- Origine
- Humain
- Hôte
- Human Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Origine
- Souris
- Hôte
- Human Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Origine
- Macaque rhésus
- Hôte
- Human Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 92 % by SDS-PAGE.
- Activité biologique
- Active
Protein
- Imm (Immunogen: Application indiquée)
- Origine
- Souris
- Hôte
- Mammalian Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- ELISA (ELISA: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 90 % as determined by reducing SDS-PAGE.
- Activité biologique
- Active
Protein
- Imm (Immunogen: Application indiquée)
- Origine
- Humain
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Imm (Immunogen: Application indiquée)
- Origine
- Rat
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Protein
- Origine
- Macaca nemestrina
- Hôte
- HEK-293 Cells
- Type Proteine
- Recombinant
- Pureté
- > 95 % as determined by reducing SDS-PAGE.
Dernières publications pour nos Proprotein Convertase Subtilisin/kexin Type 9 Protéines
: "Structure-activity analysis of truncated albumin-binding domains suggests new lead constructs for potential therapeutic delivery." dans: The Journal of biological chemistry, Vol. 295, Issue 34, pp. 12143-12152, (2021) (PubMed).
: "PCSK9 Activity Is Potentiated Through HDL Binding." dans: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." dans: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." dans: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." dans: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Calcium-Mediated Allostery of the EGF Fold." dans: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." dans: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." dans: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." dans: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
: "PCSK9 Activity Is Potentiated Through HDL Binding." dans: Circulation research, (2021) (PubMed).
: "Evolution of sequence-defined highly functionalized nucleic acid polymers." dans: Nature chemistry, Vol. 10, Issue 4, pp. 420-427, (2019) (PubMed).
: "Side chain determinants of biopolymer function during selection and replication." dans: Nature chemical biology, Vol. 15, Issue 4, pp. 419-426, (2019) (PubMed).
: "The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance." dans: JCI insight, Vol. 4, Issue 11, (2019) (PubMed).
: "Calcium-Mediated Allostery of the EGF Fold." dans: ACS chemical biology, Vol. 13, Issue 6, pp. 1659-1667, (2019) (PubMed).
: "Low-density lipoprotein (LDL)-dependent uptake of Gram-positive lipoteichoic acid and Gram-negative lipopolysaccharide occurs through LDL receptor." dans: Scientific reports, Vol. 8, Issue 1, pp. 10496, (2018) (PubMed).
: "Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia." dans: Acta diabetologica, Vol. 54, Issue 2, pp. 191-199, (2017) (PubMed).
: "The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA." dans: The Journal of biological chemistry, Vol. 292, Issue 5, pp. 1573-1590, (2017) (PubMed).
: "Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor." dans: PLoS ONE, Vol. 11, Issue 5, pp. e0155030, (2017) (PubMed).
Pseudonymes pour Proprotein Convertase Subtilisin/kexin Type 9 Protéines
proprotein convertase subtilisin/kexin type 9 (PCSK9) Protéinesproprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) Protéines
proprotein convertase subtilisin/kexin type 9 (pcsk9) Protéines
proprotein convertase subtilisin/kexin type 9 (Pcsk9) Protéines
AI415265 Protéines
AI747682 Protéines
FH3 Protéines
HCHOLA3 Protéines
LDLCQ1 Protéines
NARC-1 Protéines
NARC1 Protéines
Narc1 Protéines
PC9 Protéines
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