Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
PSA
Origine: Humain
Hôte: HEK-293 Cells
Recombinant
The purity of the protein is greater than 85 % as determined by SDS-PAGE and Coomassie blue staining.
Dernières publications pour nos Prostate Specific Antigen Protéines
Drake, White, Fuller, Igwe, Clements, Nyalwidhe, Given, Lance, Semmes: "Clinical collection and protein properties of expressed prostatic secretions as a source for biomarkers of prostatic disease." dans: Journal of proteomics, Vol. 72, Issue 6, pp. 907-17, (2009) (PubMed).
Harris, Lenz, Hankey, MacVittie, Farese, Nakajima, Hasumi, Mann: "Products of anti-CD3/anti-CD28 activated lymphocytes induce differentiation and maturation of dendritic cells and have adjuvant-like activity in vitro and in vivo." dans: Clinical immunology (Orlando, Fla.), Vol. 129, Issue 1, pp. 58-68, (2008) (PubMed).
Marshall, Rudnick, McCarthy, Mateo, Harris, McCauley, Snyder: "Interleukin-18 enhances Th1 immunity and tumor protection of a DNA vaccine." dans: Vaccine, Vol. 24, Issue 3, pp. 244-53, (2005) (PubMed).
Pseudonymes pour Prostate Specific Antigen Protéines