SH3G2 Protein (AA 1-352) (His tag)

N° du produit ABIN1098256

Protéine Recombinant SH3G2 exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour SH3G2 Protein (AA 1-352) (His tag) (ABIN1098256)

Antigène: SH3G2 (Endophilin-A1 (SH3G2))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Pureté: > 85 %

Détail du produit

Attributs du protein: AA 1-352

Purification/Conjugué: Cette SH3G2 protéine est marqué à la His tag.

Séquence: MSVAGL KKQFHKATQK VSEKVGGAEG TKLDDDFKEM ERKVDVTSRA VMEIMTKTIE YLQPNPASRA KLSMINTMSK IRGQEKGPGY PQAEALLAEA MLKFGRELGD DCNFGPALGE VGEAMRELSE VKDSLDIEVK QNFIDPLQNL HDKDLREIQH HLKKLEGRRL DFDYKKKRQG KIPDEELRQA LEKFDESKEI AESSMFNLLE MDIEQVSQLS ALVQAQLEYH KQAVQILQQV TVRLEERIRQ ASSQPRREYQ PKPRMSLEFP TGDSTQPNGG LSHTGTPKPS GVQMDQPCCR ALYDFEPENE GELGFKEGDI ITLTNQIDEN WYEGMLHGHS GFFPINYVEI LVALPH

Purification: > 85% by SDS-PAGE

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Synonyms: Endophilin-A1, CNSA2, EEN-B1, SH3D2A, SH3P4

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 20 mM Tris-HCl buffer ( pH 8.0) containing 10 % glycerol, 1 mM DTT, 50 mM NaCl

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détail du antigène

Antigène: SH3G2 (Endophilin-A1 (SH3G2))

Autre désignation: Endophilin A1/SH3GL2

Sujet: SH3GL2 (SH3-domain GRB2-like 2), also known as endophilin-A1, belongs to the endophilin family. It contains a BAR domain and a SH3 domain. Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. SH3GL2 a novel tumor suppressor gene in laryngeal squamous cell carcinoma (LSCC), induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks. Recombinant human SH3GL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Poids moléculaire: 42.5 kDa (376aa) confirmed by MALDI-TOF

NCBI Accession: NP_003017

Pathways: Neurotrophin Signaling Pathway, EGFR Downregulation