Granulin Protein (GRN) (AA 494-593) (GST tag)

N° du produit ABIN1355792

Cette protéine Recombinant Granulin est exprimée dans Wheat germ et a été mentionnée dans 3+ publications.

Aperçu rapide pour Granulin Protein (GRN) (AA 494-593) (GST tag) (ABIN1355792)

Antigène: Granulin (GRN)

Type de proteíne: Recombinant

Origine: Humain

Source: Wheat germ

Application: Western Blotting (WB), ELISA, Antibody Array (AA), Affinity Purification (AP)

Détail du produit

Attributs du protein: AA 494-593

Purification/Conjugué: Cette Granulin protéine est marqué à la GST tag.

Fonction: GRN (Human) Recombinant Protein (Q01)

Séquence: SCEKEVVSAQ PATFLARSPH VAVKDVECGE GHFCHDNQTC CRDNRQGWAC CPYRQGVCCA DRRHCCPAGF RCAARGTKCL RREAPRWDAP LRDPALRQLL

Attributs du produit: Human GRN partial ORF ( NP_002078, 494 a.a. - 593 a.a.) recombinant protein with GST-tag at N-terminal.

Purification: in vitro wheat germ expression system

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Preparation method: in vitro, wheat germ expression system
Product Quality tested by: 12.5% SDS-PAGE Stained with Coomassie Blue.

Restrictions: For Research Use only

Stockage

Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH =8.0 in the elution buffer.

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -80 °C

Stockage commentaire: Best use within three months from the date of receipt of this protein.

Référence

Chen, Chang, Deng, Xu, Nguyen, Martens, Cenik, Taylor, Hudson, Chung, Yu, Yu, Herz, Farese, Kukar, Tansey: "Progranulin does not bind tumor necrosis factor (TNF) receptors and is not a direct regulator of TNF-dependent signaling or bioactivity in immune or neuronal cells." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 21, pp. 9202-13, (2013) (PubMed).

De Muynck, Herdewyn, Beel, Scheveneels, Van Den Bosch, Robberecht, Van Damme: "The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding." dans: Neurobiology of aging, Vol. 34, Issue 11, pp. 2541-7, (2013) (PubMed).

Van Damme, Van Hoecke, Lambrechts, Vanacker, Bogaert, van Swieten, Carmeliet, Van Den Bosch, Robberecht: "Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival." dans: The Journal of cell biology, Vol. 181, Issue 1, pp. 37-41, (2008) (PubMed).

Détail du antigène

Antigène: Granulin (GRN)

Autre désignation: GRN

Sujet: Full Gene Name: granulin
Synonyms: GEP,GP88,PCDGF,PEPI,PGRN

ID gène: 2896

NCBI Accession: NM_002087