Granulin Protein (GRN) (AA 1-593)
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- Antigène Voir toutes Granulin (GRN) Protéines
- Granulin (GRN)
- Type de proteíne
- Recombinant
- Activité biologique
- Active
- Attributs du protein
- AA 1-593
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Origine
- Humain
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Source
- HEK-293 Cells
- Application
- SDS-PAGE (SDS)
- Réactivité croisée
- Humain
- Attributs du produit
- Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.
- Pureté
- >98 % (SDS-PAGE)
- niveau d'endotoxine
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product GRN Protéine
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Granulin (GRN) (AA 494-593) protein (GST tag)
GRN Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 364-430) protein (His tag)GRN Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Granulin (GRN) (AA 289-426) protein (His-IF2DI Tag)GRN Origine: Humain Hôte: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Granulin (GRN) protein (His tag)GRN Origine: Souris Hôte: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Granulin (GRN) (AA 1-593) protein (GST tag)GRN Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
Granulin (GRN) (AA 18-593) protein (His tag)Crystallography grade GRN Origine: Humain Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Granulin (GRN) (AA 18-589) protein (His tag)Crystallography grade GRN Origine: Souris Hôte: Cellules d'insectes Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Commentaires
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Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).
- Restrictions
- For Research Use only
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- Format
- Solid
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. - Date de péremption
- 6 months
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- Antigène
- Granulin (GRN)
- Autre désignation
- Progranulin (GRN Produits)
- Synonymes
- GRN Protein, grn Protein, wu:fb11g12 Protein, wu:fj18f05 Protein, MGC53354 Protein, DKFZp459H066 Protein, CLN11 Protein, GEP Protein, GP88 Protein, PCDGF Protein, PEPI Protein, PGRN Protein, epithelin Protein, acrogranin Protein, granulin precursor Protein, granulin a Protein, Granulins Protein, granulin L homeolog Protein, granulin Protein, GRN Protein, grna Protein, grn Protein, grn.L Protein, granulin Protein, ORF1 granulin Protein, Grn Protein
- Classe de substances
- Viral Protein
- Sujet
- Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
- Poids moléculaire
- ~74kDa (glycosylated protein by SDS-PAGE)
- UniProt
- P28799
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