Complement C4 Protéine

N° du produit ABIN1880330

Cette protéine Native Complement C4 est produite dans Human.

Aperçu rapide pour Complement C4 Protéine (ABIN1880330)

Antigène: Complement C4 (C4) (Complement 4 (C4))

Type de proteíne: Native

Activité biologique: Active

Origine: Humain

Source: Human

Application: ELISA

Pureté: >90 % by SDS-PAGE

Détail du produit

Purification: Purified

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 10 mM PBS ( pH 7.4).

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Shipat 4°C.Upon receipt, aliquot and store at -20°C or -80°C for long term. Avoid repeated freeze and thaw cycles.

Détail du antigène

Antigène: Complement C4 (C4) (Complement 4 (C4))

Autre désignation: Complement C4

Sujet:

Synonyms: Complement C4-A, Acidic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, C4A, CO4, CPAMD2

Description: Purified human Complement C4 protein.

Background: Complement C4encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gammachains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9.

Pathways: Système du Complément