IL1A Protein (AA 116-270)
Aperçu rapide pour IL1A Protein (AA 116-270) (ABIN2018084)
Antigène
Voir toutes IL1A ProtéinesType de proteíne
Activité biologique
Origine
Source
Pureté
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Attributs du protein
- AA 116-270
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Attributs du produit
- ED50 <5 pg/mL, measured in a proliferation assay using D10S cells.
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niveau d'endotoxine
- < 0.2 EU/μg, determined by LAL method.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Stock
- -80 °C
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Stockage commentaire
- Lyophilized recombinant Rat Interleukin-1 alpha remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Rat Interleukin-1 alpha should be stable up to 1 week at 4°C or up to 2 months at -20°C.
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Date de péremption
- 6 months
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- IL1A (Interleukin 1 alpha (IL1A))
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Autre désignation
- Interleukin-1alpha (IL-1alpha)
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Sujet
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Interleukin-1 alpha (IL-1α), is produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1alpha and IL-1beta bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including stimulation of thymocyte proliferation via IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity, and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.
Synonyms: Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF) -
Poids moléculaire
- 17-22 kDa, observed by reducing SDS-PAGE.
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UniProt
- P16598
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Pathways
- Signalisation NF-kappaB, Autophagy, Cancer Immune Checkpoints
Antigène
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