Thrombopoietin Protein (THPO) (AA 22-356)

N° du produit ABIN2018397

Protéine Recombinant Thrombopoietin exprimée dans CHO Cells.

Aperçu rapide pour Thrombopoietin Protein (THPO) (AA 22-356) (ABIN2018397)

Antigène: Thrombopoietin (THPO)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: CHO Cells

Pureté: > 95 % as analyzed by SDS-PAGE.

Détail du produit

Attributs du protein: AA 22-356

Attributs du produit: ED50 < 2 ng /mL, measured in a proliferation assay using MO7e cells.

niveau d'endotoxine: < 0.2 EU/μg, determined by LAL method.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL..

Buffer: Lyophilized after extensive dialysis against PBS.

Stock: -80 °C

Stockage commentaire: Lyophilized recombinant murine Thrombopoietin (TPO) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Thrombopoietin (TPO) should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Date de péremption: 6 months

Détail du antigène

Antigène: Thrombopoietin (THPO)

Autre désignation: Thrombopoietin (TPO)

Sujet: Thrombopoietin (TPO), also known as C-mpl ligand, MGDF and Thpo, is a glycoprotein hormone belonging to the EPO/TPO family. It is expressed mainly in the liver, kidney and skeletal muscle. TPO binds and signals through MLP/C_MPL receptor. It stimulates the proliferation and maturation of megakaryocytes from their committed progenitor cells, and it regulates the production and circulation of platelets. TPO has also been reported to promote the apoptosis of hypoxia-sensitized neurons and to inhibit neuronal differentiation.
Synonyms: Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF

Poids moléculaire: 30-80 kDa, observed by reducing SDS-PAGE.

UniProt: P40226

Pathways: Signalistation JAK/STAT, Hormone Activity