CD40 Protein (CD40) (full length)

N° du produit ABIN935307

Cette protéine Recombinant CD40 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour CD40 Protein (CD40) (full length) (ABIN935307)

Antigène: CD40

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Souris

Source: Escherichia coli (E. coli)

Pureté: > 98 % pure

Détail du produit

Attributs du protein: full length

Séquence: MQRGDEDPQI AAHVVSEANS NAASVLQWAK KGYYTMKSNL VMLENGKQLT VKREGLYYVY TQVTFCSNRE PSSQRPFIVG LWLKPSSGSE RILLKAANTH SSSQLCEQQS VHLGGVFELQ AGASVFVNVT EASQVIHRVG FSSFGLLKL

Attributs du produit: Purified recombinant Mouse CD40 protein
Expression System: E.coli
Bioactivity: Determined by its ability to induce TNF-alpha and MIP-1 alpha production by Mouse splenocytes. The expected ED50 for this effect is

Stérilité: 0.2 μm filtered

niveau d'endotoxine: < 0.1 ng per μg (1 EU/μg).

Information d'application

Indications d'application: Each Investigator should determine their own optimal working dilution for specific applications.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: Sterile filtered through a 0.2 μm filter. Lyophilized from 10 mM Na3PO4, pH 7.5 with 0.1 M arginine. Restore in water to a concentration of 0.1 - 1.0 mg/mL.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C until reconstitution. Following reconstitution aliquot and freeze at -20 °C for long term storage.

Détail du antigène

Antigène: CD40

Autre désignation: CD40

Sujet: CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to immunodeficiency with hyper-IgM, a disease characterized by failure to produce IgG, IgA and IgE. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated in vivo by an intracellular proteolytic processing of the full length CD40L.
Alternative Names: CD-40, gp39 protein, soluble CD40 Ligand protein, CD 40, CD40, CD 40 protein, TNFSF5 protein, TRAP protein, CD-40 protein, CD154 protein, T-BAM protein

Poids moléculaire: 16.4 kDa

Pathways: Signalisation NF-kappaB, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints