Thrombopoietin Protein (THPO)

N° du produit ABIN2469139

Protéine Recombinant Thrombopoietin exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour Thrombopoietin Protein (THPO) (ABIN2469139)

Antigène: Thrombopoietin (THPO)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Rat

Source: Escherichia coli (E. coli)

Pureté: < 98 % by SDS-PAGE gel and HPLC analyses.

Détail du produit

Séquence: SPVPPACDPR LLNKLLRDSY LLHSRLSQCP DVNPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPPQGRTTA HKDPSALFLS LQQLLRGKVR FLLLVEGPAL CVRRTLPTTA VPSRTSQLLT LNKF

Attributs du produit: The ED50 was determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be < 0.2 ng/mL, corresponding to a specific activity of > 5 x 10⁷ units/mg.

niveau d'endotoxine: Endotoxin level is less than 0.1 ng per μg (1 EU/μg).

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Conseil sur la manipulation: As with any protein, exposing Thrombopoeitin recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

Stock: -20 °C

Stockage commentaire: The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Thrombopoeitin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.

Date de péremption: 24 months

Détail du antigène

Antigène: Thrombopoietin (THPO)

Sujet: TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

ID gène: 81811

NCBI Accession: NP_112395

OMIM: 13592113

UniProt: P49745

Pathways: Signalistation JAK/STAT, Hormone Activity