Nef Protéine

N° du produit ABIN2669326

Cette protéine Recombinant Nef est produite dans Escherichia coli (E. coli).

Aperçu rapide pour Nef Protéine (ABIN2669326)

Antigène: Nef

Type de proteíne: Recombinant

Origine: Human Immunodeficiency Virus (HIV)

Source: Escherichia coli (E. coli)

Application: Endotoxin Detection Assay (EDA), High Pressure Liquid Chromatography (HPLC), SDS-PAGE (SDS)

Pureté: >90 %

Détail du produit

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: The protein should be reconstituted in apirogenic sterile water or 1X PBS.

Buffer: 1 % glycerol

Stock: 4 °C

Détail du antigène

Antigène: Nef

Classe de substances: Viral Protein

Sujet: HIV-1 Nef is a 27 kDa protein abundantly produced shortly after virus infection. Nef is an essential factor for efficient viral replication and pathogenesis, it also facilitates virus replication and enhances virions infectivity. Nef exerts pleiotropic effects: down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK, protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Nef protein bypasses host T-cell signaling by inducing a trascriptional program nearly identical to that of anti-CD3 cell activation.