Nef protein (Biotin)

N° du produit ABIN2669337

Détail du produit

Antigène: Nef

Type de proteíne: Recombinant

Origine: Human Immunodeficiency Virus (HIV)

Source: Escherichia coli (E. coli)

Purification/Conjugué: Biotin

Application: ELISA, Western Blotting (WB)

Attributs du produit: Recombinant (HIV-1) Nef biotin-conjugated.

Pureté: > 90 %

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 1X PBS, 0.05 % (v/v) glycerol

Stock: -20 °C

Détail du antigène

Antigène: Nef

Synonymes: F-protein Protein, nef protein Protein, nef Protein

Classe de substances: Viral Protein

Sujet: HIV-1 Nef is a 27 kDa protein abundantly produced shortly after virus infection. Nef is an essential factor for efficient viral replication and pathogenesis, it also facilitates virus replication and enhances virions infectivity. Nef exerts pleiotropic effects: down-modulates surface MHC-I molecules, decreases cell surface CD4 antigen by interacting with the Src family kinase LCK, protects the infected cell from apoptosis in order to keep it alive until the next virus generation is ready to strike. Nef protein bypasses host T-cell signaling by inducing a trascriptional program nearly identical to that of anti-CD3 cell activation.