PYCARD Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

N° du produit ABIN2713165

Cette protéine Recombinant PYCARD est exprimée dans HEK-293 Cells.

Aperçu rapide pour PYCARD Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2713165)

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Détail du produit

Attributs du protein: Transcript Variant 1

Purification/Conjugué: Cette PYCARD protéine est marqué à la Myc-DYKDDDDK Tag.

Attributs du produit:

• Recombinant human CARD5 / PYCARD / ASC (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Autre désignation: Card5,pycard,asc

Sujet: This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 21.4 kDa

NCBI Accession: NP_037390

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome