BCL2L1 Protein (Transcript Variant 2)

N° du produit ABIN2715193

Cette protéine Recombinant BCL2L1 est exprimée dans Escherichia coli (E. coli).

Aperçu rapide pour BCL2L1 Protein (Transcript Variant 2) (ABIN2715193)

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Type de proteíne: Recombinant

Origine: Humain

Source: Escherichia coli (E. coli)

Application: Antibody Production (AbP), Standard (STD)

Pureté: > 95 % as determined by SDS-PAGE and Coomassie blue staining

Détail du produit

Attributs du protein: Transcript Variant 2

Attributs du produit:

• Recombinant human Bcl-2-like 1 (transcript variant 2) protein expressed in E. coli.
• Produced with end-sequenced ORF clone

niveau d'endotoxine: < 0.1 EU per μg protein as determined by LAL test

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 20 mM HEPES, 50 mM KCl, 20 % Glycerol, pH 7.5. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: BCL2L1 (BCL2-Like 1 (BCL2L1))

Autre désignation: Bcl-2-Like 1

Sujet: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator.

Poids moléculaire: 24.8 kDa

NCBI Accession: NP_001182

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling