TPMT Protein (Myc-DYKDDDDK Tag)

N° du produit ABIN2733577

Cette protéine Recombinant TPMT est exprimée dans HEK-293 Cells.

Aperçu rapide pour TPMT Protein (Myc-DYKDDDDK Tag) (ABIN2733577)

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Type de proteíne: Recombinant

Origine: Humain

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Pureté: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Détail du produit

Purification/Conjugué: Cette TPMT protéine est marqué à la Myc-DYKDDDDK Tag.

Attributs du produit:

• Recombinant human Thiopurine methyltransferase (TPMT) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Information d'application

Indications d'application: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Commentaires:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Stockage

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Stock: -80 °C

Stockage commentaire: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Détail du antigène

Antigène: TPMT (Thiopurine S-Methyltransferase (TPMT))

Autre désignation: Thiopurine Methyltransferase (Tpmt)

Sujet: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

Poids moléculaire: 28 kDa

NCBI Accession: NP_000358