DKK1 Protein (AA 32-266)
Aperçu rapide pour DKK1 Protein (AA 32-266) (ABIN2816987)
Antigène
Voir toutes DKK1 ProtéinesType de proteíne
Activité biologique
Origine
Source
Application
Pureté
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Attributs du protein
- AA 32-266
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Séquence
- Thr32 - His266, Accession # O94907
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Attributs du produit
- Biological Activity: The ED50, as determined by inhibition of Wnt-3a induced alkaline phosphatase production using mouse MC3T3E1 cells, is less than 150 ng/mL.
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Stérilité
- 0.2 μm filtered
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Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His-Avi Tag,Biotin)
DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (His tag)DKK1 Origine: Cynomolgus, Macaque rhésus Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag)DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag,Biotin)DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-266) protein (Fc Tag)DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant The purity of the protein is greater than 90 % as determined by SDS-PAGE and Coomassie blue staining.
Dickkopf Homolog 1 (DKK1) (AA 178-266), (C-Term) protein (Fc-Avi Tag)DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Dickkopf Homolog 1 (DKK1) (AA 32-142), (N-Term) protein (Fc-Avi Tag,Biotin)DKK1 Origine: Humain Hôte: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Dickkopf Homolog 1 (DKK1) (AA 1-272) protein (His-IF2DI Tag)DKK1 Origine: Souris Hôte: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Dickkopf Homolog 1 (DKK1) (AA 81-180) protein (GST tag)DKK1 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
Dickkopf Homolog 1 (DKK1) (AA 1-242) protein (GST tag)DKK1 Origine: Humain Hôte: Wheat germ Recombinant WB, ELISA, AA, AP
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 20 mM PB, pH 7.4, 150 mM NaCl
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Stock
- -20 °C
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- DKK1 (Dickkopf Homolog 1 (DKK1))
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Autre désignation
- DKK1
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Sujet
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Relevance: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease. {ECO:0000269|PubMed:22000856}.
Synonyms: Dickkopf-1, hDkk-1, SK -
Poids moléculaire
- 25.8 kDa
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UniProt
- O94907
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Pathways
- Signalisation WNT, Regulation of Muscle Cell Differentiation, Positive Regulation of fat Cell Differentiation
Antigène
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