Granulin Protein (GRN) (AA 1-593)

N° du produit ABIN5564456

Protéine Recombinant Granulin exprimée dans HEK-293 Cells.

Aperçu rapide pour Granulin Protein (GRN) (AA 1-593) (ABIN5564456)

Antigène: Granulin (GRN)

Type de proteíne: Recombinant

Activité biologique: Active

Origine: Humain

Source: HEK-293 Cells

Application: SDS-PAGE (SDS)

Pureté: >98 % (SDS-PAGE)

Détail du produit

Attributs du protein: AA 1-593

Fonction: Progranulin (human) (rec.) (untagged)

Réactivité croisée: Humain

Attributs du produit: Signal peptide and human progranulin (aa 1-593) is untagged. Reflects the native sequence with no additional aa.

niveau d'endotoxine: <0.01EU/μg purified protein (LAL test).

Biological Activity Comment: Activates phospho-ERK1/2 in neuronal mouse P19 cells. Regulates food intake and body weight (see reference 1).

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Contains PBS.

Conseil sur la manipulation: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Stock: 4 °C,-20 °C

Stockage commentaire:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Date de péremption: 6 months

Détail du antigène

Antigène: Granulin (GRN)

Autre désignation: Progranulin

Sujet:

Proepithelin, PEPI, PC Cell-derived Growth Factor

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis. EphA2, a member of the large family of Ephrin receptor tyrosine kinases, is also a functional signaling receptor for progranulin as reported recently.

Poids moléculaire: ~74kDa (glycosylated protein by SDS-PAGE)

UniProt: P28799